Twenty years ago, Zijian Xie, Ph.D., director of the Marshall Institute for Interdisciplinary Research and professor at Marshall University Joan C. Edwards School of Medicine, discovered the scaffolding/signaling function of the Na/K-ATPase sodium pump. In honor of this milestone and the impact of Xie's discovery on cell biology, the International Journal of Molecular Sciences released a special issue featuring articles related to this scaffolding/signaling function.