To the Editor Dr Sénat and colleagues conducted a randomized clinical trial investigating the effect of glyburide or insulin on perinatal complications among women with gestational diabetes. We wonder whether the study design can be applied to most women with gestational diabetes.
The low-carbohydrate, high-fat ketogenic diet is an effective treatment for many patients who have epilepsy that fails to respond to existing anticonvulsant medications, but the detailed mechanisms behind the diet’s beneficial effects on brain activity and behavior remains to be fully elucidated. New research published in Cell points to a pivotal role for the gut microbiome in mediating the effects of the diet.
Supplements, including vitamins, minerals, and herbal products, are a huge business in the United States. US consumers spend about $30 billion on them every year. Despite uncertain benefits and possible harm, their interest in supplement use, for children as well as adults, remains undeterred.
The FDA has approved the first lotion formulation of the acne drug tretinoin to help ward off dryness, peeling, and sensitivity that often are associated with topical retinoids.
Sodium-glucose cotransporter 2 (SGLT-2) inhibitors used to treat adults with type 2 diabetes have been linked with necrotizing fasciitis of the perineum, a serious rare infection also known as Fournier gangrene, the FDA has warned.
A recently approved drug may offer complete corneal healing for some patients with neurotrophic keratitis.
Beef and poultry grown from animal cells rather than sourced from whole animals could be the future of meat production, a cardiologist-turned-biotech entrepreneur says in this Medical News article.
This Research Letter evaluates the amount of sugars found in cigarillos by brand.
This study uses e-cigarette retail sales data to estimate estimate e-cigarette sales and market share of e-cigarette sales by manufacturer in the United States during 2013-2017.
This Medical Letter review summarizes clinical studies, adverse effects, dosage, and administration for a 6% otic suspension formulation of the fluoroquinolone antibiotic ciprofloxacin (Otiprio), approved by the US Food and Drug Administration in 2018 for single-dose treatment of acute otitis externa.
An asymptomatic 66-year-old man had a 3.1-cm left adrenal mass detected on CT scan with normal vital signs, BMI of 37, normal physical examination, and an elevated cortisol level after an overnight 1-mg dexamethasone suppression test. What would you do next?
This narrative review summarizes current evidence regarding the pathophysiology, diagnosis, and treatment of rheumatoid arthritis.
This meta-analysis of randomized trials assesses the association of thyroid hormone therapy with quality of life (QOL) and thyroid-related symptoms in nonpregnant adults with subclinical hypothyroidism.
This cohort study of black and white adults investigates demographic, physical, and lifestyle factors that might account for differences in incidence of hypertension in black vs white US adults.
This noninferiority trial compares the effects of arthroscopic partial meniscectomy vs physical therapy on patient-reported knee function in patients with meniscal tears.
Knee arthroscopy is among the most common surgical procedures performed worldwide. Each year, an estimated 500 000 meniscus procedures are performed in patients older than age 45 years in the United States and more than 2 million procedures are performed worldwide. Magnetic resonance imaging studies indicate that 60% of individuals without knee pain older than 50 years have evidence of meniscus degeneration, which often occurs in the presence of osteoarthritis (OA). In symptomatic patients, the clinical... Читать дальше...
In this narrative medicine essay, a geriatric and palliative care physician shares his understanding that the patience, flexibility, humility, and presence required to grow a garden are entirely appropriate for end-of-life patient care.
This viewpoint discusses increased life expectancy and the initiatives to address the risks and unintended consequences of living longer.
This Viewpoint discusses targeting fundamental biological aging processes through nutritional, genetic, and pharmacologic interventions to delay or prevent the onset or progression of multiple chronic diseases and debilities typically observed in older humans to enhance and extend both health and longevity.
This Viewpoint describes the processes by which aging of cells contributes to age-related decline, chronic disease, and multimorbidity, and describes current animal research and clinical trials investigating the effects of senolytic drugs and vaccines that target senescent cell antiapoptotic pathways and remove senescent cells.
In this Viewpoint, Don Berwick and colleagues summarize a 2018 National Academies of Sciences, Engineering, and Medicine (NASEM) report on global health care quality emphasizing that universal access will yield improvements in population health only when paired with quality reforms characterized by systems design, transparency, collaboration, anticipatory care, evidence-based decisions, and continuous feedback and learning.
In this Viewpoint, Anthony Fauci summarizes the National Institute of Allergy and Infectious Diseases’ (NIAID’s) 2018 Strategic Plan for Tuberculosis (TB), which comprises investments in development of point-of-care diagnostics, vaccines, shorter-duration therapeutics, and infrastructure for systems biology and “omics” approaches to the infection.
Despite winning regulatory approval for a copycat version of Copaxone earlier this year, Cambridge, Mass.-based Momenta Pharmaceuticals has completed a strategic review that includes slashing its staff by 50 percent as the company focuses its resources on two biosimilar candidates in its pipeline.
Personalized medicine continues to grow in importance, and having the ability to monitor health data has proven to be a significant desire for people as the number of wearable devices continues to grow.