Biogenesis of P-TEFb in CD4+ T cells to reverse HIV latency is mediated by protein kinase C (PKC)-independent signaling pathways
by Uri Mbonye, Konstantin Leskov, Meenakshi Shukla, Saba Valadkhan, Jonathan Karn
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by Uri Mbonye, Konstantin Leskov, Meenakshi Shukla, Saba Valadkhan, Jonathan Karn
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by Jonathan Youngs, Nicholas M. Provine, Nicholas Lim, Hannah R. Sharpe, Ali Amini, Yi-Ling Chen, Jian Luo, Matthew D. Edmans, Panagiota Zacharopoulou, Wentao Chen, Oliver Sampson, Robert Paton, William J. Hurt, David A. Duncan, Anna L. McNaughton, Vincent N. Miao, Susannah Leaver, Duncan L. A. Wyncoll, Jonathan Ball, Philip Hopkins, Oxford Immunology Network Covid-19 response T cell Consortium , Oxford Protective T cell Immunology for COVID-19 (OPTIC) Clinical team , Donal T. Skelly, Eleanor Barnes... Читать дальше...
by Lisanne C. de Jong, Sandra Crnko, Toine ten Broeke, Niels Bovenschen
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by Janna Heide, Sophia Schulte, Matin Kohsar, Thomas Theo Brehm, Marissa Herrmann, Hendrik Karsten, Matthias Marget, Sven Peine, Alexandra M. Johansson, Alessandro Sette, Marc Lütgehetmann, William W. Kwok, John Sidney, Julian Schulze zur Wiesch
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by Patrick J. Keeling, Varsha Mathur, Waldan K. Kwong
by Nathan P. Crilly, Monica R. Mugnier
Trypanosoma brucei is a protozoan parasite that causes human and animal African trypanosomiases (HAT and AAT). In the mammalian host, the parasite lives entirely extracellularly, in both the blood and interstitial spaces in tissues. Although most T. brucei research has focused on the biology of blood- and central nervous system (CNS)-resident parasites, a number of recent studies have highlighted parasite reservoirs in the dermis and adipose tissue,... Читать дальше...
by Josie F. Gibson, Grace R. Pidwill, Oliver T. Carnell, Bas G. J. Surewaard, Daria Shamarina, Joshua A. F. Sutton, Charlotte Jeffery, Aurélie Derré-Bobillot, Cristel Archambaud, Matthew K. Siggins, Eric J. G. Pollitt, Simon A. Johnston, Pascale Serror, Shiranee Sriskandan, Stephen A. Renshaw, Simon J. Foster
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by Yuki Kurebayashi, Shringkhala Bajimaya, Masahiro Watanabe, Nicholas Lim, Michael Lutz, Megan Dunagan, Toru Takimoto
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by Qi-Xin Hu, Hui-Yi Wang, Lu Jiang, Chen-Yu Wang, Lin-Gao Ju, Yuan Zhu, Bo Zhong, Min Wu, Zhen Wang, Lian-Yun Li
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by Wakako Furuyama, Kyle Shifflett, Heinz Feldmann, Andrea Marzi
Ebola virus (EBOV) expresses three different glycoproteins (GPs) from its GP gene. The primary product, soluble GP (sGP), is secreted in abundance during infection. EBOV sGP has been discussed as a potential pathogenicity factor, however, little is known regarding its functional role. Here, we analyzed the role of sGP in vitro and in vivo. We show that EBOV sGP has two different functions that contribute to infectivity in tissue culture. Читать дальше...
by Zong He Zhu, Abdul Sami, Qing Qing Xu, Ling Ling Wu, Wen Yin Zheng, Zhi Peng Chen, Xue Zhi Jin, Hong Zhang, Yong Li, Yan Yu, Ke Jin Zhou
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by Seung-Soo Kim, Adam D. Hudgins, Jiping Yang, Yizhou Zhu, Zhidong Tu, Michael G. Rosenfeld, Teresa P. DiLorenzo, Yousin Suh
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by Kipling Squier, Alexander Scott, Michael A. Hunt, Liam R. Brunham, David R. Wilson, Hazel Screen, Charlie M. Waugh
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by Norha Vera San Juan, Prisha Shah, Merle Schlief, Rebecca Appleton, Patrick Nyikavaranda, Mary Birken, Una Foye, Brynmor Lloyd-Evans, Nicola Morant, Justin J. Needle, Alan Simpson, Natasha Lyons, Luke Sheridan Rains, Zainab Dedat, Sonia Johnson
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by Collins Okoyo, Edward Githinji, Ruth W. Muia, Janet Masaku, Judy Mwai, Lilian Nyandieka, Stephen Munga, Sammy M. Njenga, Henry M. Kanyi
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by Angela E. Oyo-Ita, Patrick Hanlon, Ogonna Nwankwo, Xavier Bosch-Capblanch, Dachi Arikpo, Ekperonne Esu, Christian Auer, Martin Meremikwu
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by Silvia Speca, Caroline Dubuquoy, Christel Rousseaux, Philippe Chavatte, Pierre Desreumaux, Paolo Spagnolo
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by Xiaojia Guo, Jing Zhang, Xueling Wu
The outbreak of a novel coronavirus pneumonia (COVID-19), wherein more than 200 million people have been infected and millions have died, poses a great threat to achieving the United Nations 2030 sustainable development goal (SDGs). Based on the Baidu index of ’novel coronavirus’, this paper analyses the spatial and temporal characteristics of and factors that influenced the attention network for COVID-19 from January 9, 2020, to April 15, 2020. The study found that (1) Temporally... Читать дальше...
by Shengbin Liang, Tongtong Jiao, Wencai Du, Shenming Qu
To solve the problem of one-sided pursuit of the shortest distance but ignoring the tourist experience in the process of tourism route planning, an improved ant colony optimization algorithm is proposed for tourism route planning. Contextual information of scenic spots significantly effect people’s choice of tourism destination, so the pheromone update strategy is combined with the contextual information such as weather and comfort... Читать дальше...
by Fabian Kleinke, Sabina Ulbricht, Marcus Dörr, Peter Penndorf, Wolfgang Hoffmann, Neeltje van den Berg
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by Hindum Lanyero, Moses Ocan, Celestino Obua, Cecilia Stålsby Lundborg, Katureebe Agaba, Joan N. Kalyango, Jaran Eriksen, Sarah Nanzigu
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by Martin R. Edelmann, Simon Hauri
Labelling of therapeutic antibodies with radionuclides or fluorophores is routinely used to study their pharmacokinetic properties. A critical assumption in utilizing labelled therapeutic antibodies is that the label has no unfavourable effects on antibody charge, hydrophobicity, or receptor affinity. Ideally, the labelled protein should not have any significant deviations from the physiological properties of the original molecule. This article describes... Читать дальше...
by Jisoo A. Kwon, Gregory J. Dore, Behzad Hajarizadeh, Maryam Alavi, Heather Valerio, Jason Grebely, Rebecca Guy, Richard T. Gray
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by Friederike Kobel, Yesim Erim, Eva Morawa
BackgroundWe investigated, if migration status, and additional sociodemographic and clinical factors, are associated with somatization and depressiveness at admission and with remission after inpatient psychotherapy.
MethodsMultiple linear and binary logistic regression analyses were used to identify predictors for severity of somatoform and depressive symptoms at admission of inpatient psychotherapy (T0), and for remission after inpatient psychotherapy (T1). Читать дальше...
by Firoz Ahmed, Fahmida Akter Oni, Sk. Sharafat Hossen
There is a high prevalence of gender gap in Bangladesh which might affect women’s likelihood to receive maternal healthcare services. In this backdrop, we aim to investigate how gender inequality measured by intrahousehold bargaining power (or autonomy) of women and their attitudes towards intimate partner violence (IPV) affects accessing and utilizing maternal health care services. We used Bangladesh Demographic and Health Survey (BDHS)... Читать дальше...