On cross-ancestry cancer polygenic risk scores
by Lars G. Fritsche, Ying Ma, Daiwei Zhang, Maxwell Salvatore, Seunggeun Lee, Xiang Zhou, Bhramar Mukherjee
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by Lars G. Fritsche, Ying Ma, Daiwei Zhang, Maxwell Salvatore, Seunggeun Lee, Xiang Zhou, Bhramar Mukherjee
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by Milad Ghomlaghi, Guang Yang, Sungyoung Shin, David E. James, Lan K. Nguyen
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by Eric W. Bridgeford, Shangsi Wang, Zeyi Wang, Ting Xu, Cameron Craddock, Jayanta Dey, Gregory Kiar, William Gray-Roncal, Carlo Colantuoni, Christopher Douville, Stephanie Noble, Carey E. Priebe, Brian Caffo, Michael Milham, Xi-Nian Zuo, Consortium for Reliability and Reproducibility , Joshua T. Vogelstein
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by Suchinta Arif, Melanie Duc Bo Massey, Natalie Klinard, Julie Charbonneau, Loay Jabre, Ana Barbosa Martins, Danielle Gaitor, Rhiannon Kirton, Catalina Albury, Karma Nanglu
by Jaie Woodard, Wei Zheng, Yang Zhang
Three-dimensional structures of proteins can provide important clues into the efficacy of personalized treatment. We perform a structural analysis of variants within three inherited lysosomal storage disorders, comparing variants responsive to pharmacological chaperone treatment to those unresponsive to such treatment. We find that predicted ΔΔG of mutation is higher on average for variants unresponsive to treatment, in the case of datasets for both Fabry disease and Pompe disease... Читать дальше...
by Adrienn Szabó, Katalin Schlett, Attila Szücs
Activity-dependent regulation of intrinsic excitability has been shown to greatly contribute to the overall plasticity of neuronal circuits. Such neuroadaptations are commonly investigated in patch clamp experiments using current step stimulation and the resulting input-output functions are analyzed to quantify alterations in intrinsic excitability. However, it is rarely addressed, how such changes translate to the function of neurons when they operate under natural synaptic inputs. Читать дальше...
by Juan L. Trincado, Marina Reixachs-Solé, Judith Pérez-Granado, Tim Fugmann, Ferran Sanz, Jun Yokota, Eduardo Eyras
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by Eduarda Susin, Alain Destexhe
Gamma oscillations are widely seen in the awake and sleeping cerebral cortex, but the exact role of these oscillations is still debated. Here, we used biophysical models to examine how Gamma oscillations may participate to the processing of afferent stimuli. We constructed conductance-based network models of Gamma oscillations, based on different cell types found in cerebral cortex. The models were adjusted to extracellular unit recordings in humans, where... Читать дальше...
by Alison Pereira Ribeiro, Nádia Felix Felipe da Silva, Fernanda Neiva Mesquita, Priscila de Cássia Souza Araújo, Thierson Couto Rosa, José Neiva Mesquita-Neto
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by Jai Y. Yu, Loren M. Frank
The receptive field of a neuron describes the regions of a stimulus space where the neuron is consistently active. Sparse spiking outside of the receptive field is often considered to be noise, rather than a reflection of information processing. Whether this characterization is accurate remains unclear. We therefore contrasted the sparse, temporally isolated spiking of hippocampal CA1 place cells to the consistent, temporally adjacent spiking seen within their spatial receptive fields (“place fields”). Читать дальше...
by Akshay Markanday, Junya Inoue, Peter W. Dicke, Peter Thier
Purkinje cell (PC) discharge, the only output of cerebellar cortex, involves 2 types of action potentials, high-frequency simple spikes (SSs) and low-frequency complex spikes (CSs). While there is consensus that SSs convey information needed to optimize movement kinematics, the function of CSs, determined by the PC’s climbing fiber input, remains controversial. While initially thought to be specialized in reporting information... Читать дальше...
There’s a place just 90 minutes’ drive from Berlin where Angela Merkel can escape the crucible of her office, see the people who’ve known her longest and let her hair down. The picturesque town of Templin, population 16,000, is celebrating its 750th birthday this year, one year late due to the coronavirus pandemic. Video: Raphaelle Logerot / AFPTV / AFP Set in the verdant Uckermark, dotted with glistening lakes hidden in lush pine forests, it’s where Merkel grew up and has served as a sanctuary... Читать дальше...
Red Bull X-Alps athletes go on to dominate summer events
'Sherlock Holmes Chapter One' Gets PS5, Xbox Series X|S and PC Release Date, Shows Off Gameplay - Trailer
Tyron Woodley during his fight with Jake Paul. | Photo by Jason Miller/Getty Images
Looks like we won’t be seeing Jake Paul vs. Tyron Woodley 2 any time soon.
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Photo by John Fisher/Getty Images
A lot of Angels news, none of it good.
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The party needs to stay united to pass its $3.5 trillion proposal without GOP support.
Global oil and gas prices will remain higher for longer as companies resist the urge to ramp up production, the chief executive of Chevron, Mike Wirth told Bloomberg in an interview. One of the reasons for this reluctance to produce more is that investors are not on board with it, Bloomberg notes. Indeed, investors in oil and gas have become quite nervous about the long-term future of their investments there and have prioritized cash returns now rather than later. The other reason is weak equity markets, according to Wirth. Читать дальше...
Apple's redesigned camera system brings more screen real estate, but its new notch may have a lot in common with this Pixel phone.
Secondhand goods, especially fashion and luxury items, have exploded in popularity. How have investors reacted to this growing trend?
Robert Farley
U.S. Air Force, United States
The Pentagon's proposal for its next batch of fighters upends conventional defense thinking.
Here's What You Need To Remember: For quite a long time the United States has justified its fighter aircraft projects on a combination of military necessity and military Keynesianism. Expensive fighters provide advanced military capability, but also provide jobs and investment across a broad swath of communities.
The “New Century... Читать дальше...
Parents and students wait in line to check for each student’s name on a list or to present their QR code for entrance to the campus at Lankershim Elementary School in the neighborhood of North Hollywood in Los Angeles.
From the stealth-oriented Foreclosed to the twin-sticky The Ascent, there has been a bumper crop of cyberpunk shooters this year, their endless gun fests typically set amidst a gaudy onslaught of neon-tinged billboards, metallic skyscrapers and indiscriminately-placed Asian motifs.
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Struggling to fall asleep? The 4-7-8 method is a simple breathwork technique which can help you fall asleep in less than a minute, while also offering a wealth of other health benefits. Vogue learns how to do it.
The Great Divide is a recurring feature here at MMA Fighting in which our staff debate a topic in the world of MMA — news, a fight, a crazy thing somebody did, a crazy thing somebody didn’t do, or some moral dilemma threatening the very foundation of the sport — and try to figure out a resolution. We’d love for you to join in the discussion in the comments below.
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