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Новости за 17.05.2022

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Prohaptoglobin inhibits the transforming growth factor-β-induced epithelial-to-mesenchymal transition in vitro by increasing Smad1/5 activation and suppressing the Smad2/3 signaling pathway in SK-Hep1 liver cancer cells

Plos.org 
En

by Mi-Kyung Oh, Hansol Joo, In-Sook Kim

Transforming growth factor-β (TGF-β) is an important inducer of the epithelial-to-mesenchymal transition (EMT) in various cancers. Our previous study demonstrated that prohaptoglobin (proHp) stimulates Smad1/5 activation via ALK1, a TGF-β type I receptor, in endothelial cells, suggesting that proHp plays a role in TGF-β signaling. However, the function of proHp in cellular events downstream of Smads remains unclear. The current study investigated the... Читать дальше...

Авторские публикации Smi24.net

DOCKGROUND membrane protein-protein set

Plos.org 
En

by Ian Kotthoff, Petras J. Kundrotas, Ilya A. Vakser

Membrane proteins are significantly underrepresented in Protein Data Bank despite their essential role in cellular mechanisms and the major progress in experimental protein structure determination. Thus, computational approaches are especially valuable in the case of membrane proteins and their assemblies. The main focus in developing structure prediction techniques has been on soluble proteins, in part due to much greater availability of the structural data. Читать дальше...

On the choice of the best chunk size for the speculative execution of loops

Plos.org 
En

by Alvaro Estebanez, Diego R. Llanos, David Orden, Belen Palop

Loops are a rich source of parallelism. Unfortunately, many loops cannot be safely parallelized at compile time because the compiler is not able to guarantee that there will be no dependence violations. Thread-Level Speculation (TLS) techniques, either hardware or software-based, allow the parallel execution of non-analyzable loops, issuing the execution of blocks of consecutive iterations (called chunks) while a hardware or software... Читать дальше...



Tsunamites versus tempestites: Various types of redeposited stromatoporoid beds in the Devonian of the Holy Cross Mountains (Poland), a case study from the Ołowianka Quarry

Plos.org 
En

by Piotr Łuczyński

The sedimentary history of two stromatoporoid accumulations ‒ an allobiostrome and a parabiostrome–are studied in the shallow water carbonates of the Middle to Upper Devonian Kowala Formation in the Ołowianka Quarry, Holy Cross Mountains, central Poland. Sedimentological and facies observations are accompanied by morphometrical and taphonomical analyses of redeposited stromatoporoid skeletons. Stromatoporoid features, including shape profile, latilaminae arrangement, surface character... Читать дальше...

Cognitive workload evaluation of landmarks and routes using virtual reality

Plos.org 
En

by Usman Alhaji Abdurrahman, Lirong Zheng, Shih-Ching Yeh

Investigating whether landmarks and routes affect navigational efficiency and learning transfer in traffic is essential. In this study, a virtual reality-based driving system was employed to determine the effects of landmarks and routes on human neurocognitive behavior. The participants made four (4) journeys to predetermined destinations. They were provided with different landmarks and routes to aid in reaching their respective destinations. Читать дальше...

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В НОВОМ ОТЧЕТЕ LG ОБ УСТОЙЧИВОМ РАЗВИТИИ ОТМЕЧЕН ПРОГРЕСС В ДОСТИЖЕНИИ ЭКОЛОГИЧЕСКИХ ЦЕЛЕЙ 2030 ГОДА Жители Прикамья активно покупают билеты на транспорт в отделениях Почты России Михаил Прохоров выходит на страховой рынок с новой компанией «Медиана» В России снизилась цена вторичного жилья

The normal stages of development for the California valley quail

Plos.org 
En

by Shelby M. Perry, Jeffrey G. Whitt, Kelly S. Reyna

One challenge in avian embryology is establishing a standard developmental timetable, primarily because eggs incubated for identical durations can vary in developmental progress, even within the same species. For remedy, avian development is classified into distinct stages based on the formation of key morphological structures. Developmental stages exist for a few galliform species, but the literature is lacking a description of normal... Читать дальше...

In vitro comparison of various antioxidants and flavonoids from Rooibos as beta cell protectants against lipotoxicity and oxidative stress-induced cell death

Plos.org 
En

by Céline Moens, Christo J. F. Muller, Luc Bouwens

Oxidative stress and lipotoxicity effects on pancreatic β cells play a major role in the pathogenesis of type 2 diabetes (T2D). Flavonoids and antioxidants are under study for their cytoprotective effects and antidiabetic potential. In this study, we aimed to compare the protective effect of the Rooibos components aspalathin, isoorientin, 3-hydroxyphloretin (3-OH) and green Rooibos extract (GRT) itself, and exendin-4 and N-acetylcysteine (NAC) as reference molecules... Читать дальше...

Спонсорский контент
Russia24.pro
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Ria.city
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Ru24.net
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Smi24.net
Британец с раком мозга рассказал о симптоме, который спас ему жизнь ЦИК: В 37 регионах голосование в сентябре будет трехдневным Раввин Борода: Вклад Митты в формирование ключевых этапов киноиндустрии «Ведомости» узнали о смене собственника у ТЦ «Дарья» и «Пассаж» на западе Москвы

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