The new trailer for Andor has landed, and it comes bearing gifts—namely, glimpses of all-new characters and an official release date. Disney+ dropped an initial teaser for the series at the end of May as part of Star Wars Celebration 2022, but the new full-length trailer offers glimpses of the all the action the…
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Forbes’ flagship Under 30 Summit, will convene more than 2,500 young leaders and entrepreneurs who are paving the path forward in their respective fields.
A week later, the two postrace disqualifications at Pocono are still the talk of the NASCAR Cup Series, Bob Pockrass writes.
Maren Morris, Ellie Goulding and En Vogue headline the 2023 Hilton Grand Vacations Tournament Of Champions Concert Series. The three-day event, held in Orlando, Florida’s Lake Nona January 2023, boasts an all-female genre-spanning musical lineup.
A collaboration led by scientists at Nagoya University in Japan has investigated the nature of dark matter surrounding galaxies seen as they were 12 billion years ago, billions of years further back in time than ever before. Their findings, published in Physical Review Letters, offer the tantalizing possibility that the fundamental rules of cosmology may differ when examining the early history of our universe.
Today, NOAA Fisheries announced proposed changes to vessel speed regulations to further protect North Atlantic right whales from death and serious injuries resulting from collisions—part of a multifaceted approach to stabilize and recover this endangered population. The changes would expand the current mandatory seasonal speed restrictions of 10 knots or less in designated areas of the ocean and extend to most vessels measuring 35 to 65 feet in length.
Millennials have reached their peak earning years. And these business careers offer the best chance for higher salaries and career growth.
By Cezary Jan Strusiewicz Published: August 01st, 2022
Provenance has never been more important for collectors of rare diamonds and gemstones. WILLIAM GANT unveils the ‘mysteries’ of the fancy colour diamond market.
Australia’s Leonard Joel will host an Important Jewels auction on 16 August, headlined by a dazzling 21.13-carat diamond ring.
Keith Thurman has he was hampered by injuries when he beat Danny Garcia the first time, and believes he’d do so in even better fashion in a rematch. | Photo by Bill Tompkins/Getty Images
Thurman beat Garcia by split decision back in 2017.
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Retail Edge has released the sales performance report for July, revealing significant positive indicators for domestic retailers.
A priceless stash of jewellery has been discovered in the wreck of a Spanish galleon that sunk in the Bahamas in the 1600s.
by İçten Meraş, Laëtitia Chotard, Thomas Liontis, Zakaria Ratemi, Benjamin Wiles, Jung Hwa Seo, Jeremy M. Van Raamsdonk, Christian E. Rocheleau
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by David Giacalone, Rochelle E. Yap, Alwyn M. V. Ecker, Shumin Tan
The ability of Mycobacterium tuberculosis (Mtb) to adapt to its surrounding environment is critical for the bacterium to successfully colonize its host. Transcriptional changes are a vital mechanism by which Mtb responds to key environmental signals experienced, such as pH, chloride (Cl-), nitric oxide (NO), and hypoxia. However, much remains unknown regarding how Mtb coordinates its response to the disparate signals seen during infection. Читать дальше...
by Nora Heitzman-Breen, Stanca M. Ciupe
The relationship between transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the amount of virus present in the proximity of a susceptible host is not understood. Here, we developed a within-host and aerosol mathematical model and used it to determine the relationship between viral kinetics in the upper respiratory track, viral kinetics in the aerosols, and new transmissions in golden hamsters challenged with SARS-CoV-2. Читать дальше...
by Anup Gopalakrishna Pillai, Suhita Nadkarni
Accumulation of amyloid-beta (Aβ) is associated with synaptic dysfunction and destabilization of astrocytic calcium homeostasis. A growing body of evidence support astrocytes as active modulators of synaptic transmission via calcium-mediated gliotransmission. However, the details of mechanisms linking Aβ signaling, astrocytic calcium dynamics, and gliotransmission are not known. We developed a biophysical model that describes calcium signaling... Читать дальше...
by Grégory Dumont, Alberto Pérez-Cervera, Boris Gutkin
Brain rhythms emerge from synchronization among interconnected spiking neurons. Key properties of such rhythms can be gleaned from the phase-resetting curve (PRC). Inferring the PRC and developing a systematic phase reduction theory for large-scale brain rhythms remains an outstanding challenge. Here we present a theoretical framework and methodology to compute the PRC of generic spiking networks with emergent collective oscillations. Читать дальше...
This Queen Anne style home of the Colwell-Dorset family stood at 330 South 6th Street, La Crosse, from 1888 to 1966. It replaced the original family home to the east. When the last survivor, Helen Dorset, died in 1965, as…
The EU and the UK have slowed efforts to have Russia shut off from the most important maritime insurance market amid concerns that a full insurance ban would limit global oil supply and push oil prices even higher, the Financial Times reports, citing UK and EU officials. The UK was set to join an EU insurance ban after the UK and the European Union agreed in May to jointly shut off Russia's access to oil cargo insurance. Under those plans, Russia would be effectively shut out of more than 90% of the global oil shipment insurance market. Читать дальше...
The installation is a result of the collaboration by the international team composed of Claudio Araya (Chile), Yahya Abdullah (Canada), and Iga Majorek (Poland) in collaboration with AMDL Circle, the architecture studio led by Michele De Lucchi (architects of record). Commissioned to design the facade for Silk-FAW’s grand reveals of the Hongqi S9 electric supercar at the Fuorisalone 2021 design week, the proposal poses the question of the reveal itself.
by Xueting Huang, Xiuyuan Li, Haoran An, Juanjuan Wang, Ming Ding, Lijun Wang, Lulu Li, Quanjiang Ji, Fen Qu, Hui Wang, Yingchun Xu, Xinxin Lu, Yuan He, Jing-Ren Zhang
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by Aakriti Gangwal, Nitika Sangwan, Neha Dhasmana, Nishant Kumar, Chetkar Chandra Keshavam, Lalit K. Singh, Ankur Bothra, Ajay K. Goel, Andrei P. Pomerantsev, Stephen H. Leppla, Yogendra Singh
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by Roshni R. Kharadi, Kayla Selbmann, George W. Sundin
Cyclic-di-GMP (c-di-GMP) is an essential bacterial second messenger that regulates biofilm formation and pathogenicity. To study the global regulatory effect of individual components of the c-di-GMP metabolic system, we deleted all 12 diguanylate cyclase (dgc) and phosphodiesterase (pde)-encoding genes in E. amylovora Ea1189 (Ea1189Δ12). Ea1189Δ12 was impaired in surface attachment due to a transcriptional dysregulation of the type IV pilus and the flagellar filament. Читать дальше...
by Chunyan Han, Dun Zhang, Chenwu Gui, Liang Huang, Sijia Chang, Lianghui Dong, Lei Bai, Shuwen Wu, Ke Lan
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