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Новости за 17.03.2023

Retrofit House 275 / IN arq+design

Archdaily.com 

Initially known as Casa MIC, Curitiba's iconic brutalist residence, it is an original project of renowned architect Manoel Coelho, built in 1981, where he and his family lived for 40 years.

The histone chaperone NASP maintains H3-H4 reservoirs in the early Drosophila embryo

Plos.org 

by Reyhaneh Tirgar, Jonathan P. Davies, Lars Plate, Jared T. Nordman

Histones are essential for chromatin packaging, and histone supply must be tightly regulated as excess histones are toxic. To drive the rapid cell cycles of the early embryo, however, excess histones are maternally deposited. Therefore, soluble histones must be buffered by histone chaperones, but the chaperone necessary to stabilize soluble H3-H4 pools in the Drosophila embryo has yet to be identified. Here, we show that CG8223... Читать дальше...

PCB: A pseudotemporal causality-based Bayesian approach to identify EMT-associated regulatory relationships of AS events and RBPs during breast cancer progression

Plos.org 

by Liangjie Sun, Yushan Qiu, Wai-Ki Ching, Pu Zhao, Quan Zou

During breast cancer metastasis, the developmental process epithelial-mesenchymal (EM) transition is abnormally activated. Transcriptional regulatory networks controlling EM transition are well-studied; however, alternative RNA splicing also plays a critical regulatory role during this process. Alternative splicing was proved to control the EM transition process, and RNA-binding proteins were determined to regulate alternative splicing. Читать дальше...



ProInfer: An interpretable protein inference tool leveraging on biological networks

Plos.org 

by Hui Peng, Limsoon Wong, Wilson Wen Bin Goh

In mass spectrometry (MS)-based proteomics, protein inference from identified peptides (protein fragments) is a critical step. We present ProInfer (Protein Inference), a novel protein assembly method that takes advantage of information in biological networks. ProInfer assists recovery of proteins supported only by ambiguous peptides (a peptide which maps to more than one candidate protein) and enhances the statistical confidence for proteins supported by both unique and ambiguous peptides. Читать дальше...

Elephant Rumblings: Four A’s are out of options

Athletics Nation 

Darren Yamashita-USA TODAY Sports

MLB news roundup

Happy Friday, Athletics Nation!

Don’t drop that ball, Cristian Pache!

That isn’t so much a worry for the young outfielder, who is renowned for his elite defensive skills. The real worry is that his hitting was terrible last year: In 260 plate appearances, Pache slashed .166/.218/.241 with a wRC+ of 35 for the A’s in 2022. To top it off, the 24-year-old centerpiece of the Matt Olson trade is one of four Athletics who... Читать дальше...

Nate Eaton deserves a good, long look

Royals Review 

Nate Eaton #18 of the Kansas City Royals gives high-fives to teammates after scoring in the top of the first against the Milwaukee Brewers at American Family Fields of Phoenix on March 11, 2023 in Phoenix, Arizona. | Photo by Patrick Mulligan/Getty Images

An intriguing player

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Chicago Med Season 8 Episode 16 Spoilers: Med and Fire Join Forces, But Will They Avert Tragedy?

Блог сайта «Face Tube is a fun name,» 

The long wait is over.

It's been a month since we checked in with our friends at the Gaffney Medical Center, but the series is back on March 22.

Chicago Med Season 8 Episode 16 will make up for the long hiatus by getting viewers' adrenaline pumping during a high-stakes rescue story. And CFD will assist in a semi-crossover between Med and Chicago Fire.

Before COVID, characters traveled between One Chicago shows regularly. Med's original premise was a semi-crossover... Читать дальше...





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