by Hamadoun Touré, Lee Ann Galindo, Marion Lagune, Simon Glatigny, Robert M. Waterhouse, Isabelle Guénal, Jean-Louis Herrmann, Sébastien Szuplewski, Fabienne Girard-Misguich
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by Monica Dallmann-Sauer, Yong Zhong Xu, Ana Lúcia França da Costa, Shao Tao, Tiago Araujo Gomes, Rhana Berto da Silva Prata, Wilian Correa-Macedo, Jérémy Manry, Alexandre Alcaïs, Laurent Abel, Aurélie Cobat, Vinicius M. Fava, Roberta Olmo Pinheiro, Flavio Alves Lara, Christian M. Probst, Marcelo T. Mira, Erwin Schurr
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by Jason L. Larabee, D. Annie Doyle, Ummey Khalecha Bintha Ahmed, Tyler M. Shadid, Rachel R. Sharp, Kenneth L. Jones, Young Mi Kim, Shibo Li, Jimmy D. Ballard
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by Xuesheng Wu, Maite Goebbels, Lemeng Chao, Tom Wennekes, Frank J. M. van Kuppeveld, Erik de Vries, Cornelis A. M. de Haan
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by Jiawen Fu, Lin Zhao, Juan Yang, Heming Chen, Shinuo Cao, Honglin Jia
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by Feifei Diao, Chenlong Jiang, Yangyang Sun, Yanni Gao, Juan Bai, Hans Nauwynck, Xianwei Wang, Yuanqi Yang, Ping Jiang, Xing Liu
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by Bo Yang, Yueyang Yan, Dongqiang Wang, Ying Zhang, Jigang Yin, Guan Zhu
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by Priscila Silva Grijó Farani, Beatriz Iandra da Silva Ferreira, Khodeza Begum, Glaucia Vilar-Pereira, Isabela Resende Pereira, Edith Araceli Fernández Figueroa, Roberto Alejandro Cardenas-Ovando, Igor C. Almeida, Sourav Roy, Joseli Lannes-Vieira, Otacilio Cruz Moreira
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by Michael L. McHenry, Jason Simmons, Hyejeong Hong, LaShaunda L. Malone, Harriet Mayanja-Kizza, William S. Bush, W. Henry Boom, Thomas R. Hawn, Scott M. Williams, Catherine M. Stein
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by Trudy-Ann Grant, Mario López-Pérez, Jose Manuel Haro-Moreno, Salvador Almagro-Moreno
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by Jessica C. Nelson, Hannah Shoenhard, Michael Granato
Habituation is a foundational learning process critical for animals to adapt their behavior to changes in their sensory environment. Although habituation is considered a simple form of learning, the identification of a multitude of molecular pathways including several neurotransmitter systems that regulate this process suggests an unexpected level of complexity. How the vertebrate brain integrates these various pathways to accomplish habituation learning... Читать дальше...
by Leon M. J. Mugenzi, Theofelix A. Tekoh, Sulaiman S. Ibrahim, Abdullahi Muhammad, Mersimine Kouamo, Murielle J. Wondji, Helen Irving, Jack Hearn, Charles S. Wondji
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by Christopher A. Ayoub, Connor S. Wagner, Jeff Kuret
Neurofibrillary lesions composed of tau protein aggregates are defining hallmarks of Alzheimer’s Disease. Despite tau filaments appearing to spread between networked brain regions in a prion-like manner, certain areas including cerebellum resist trans-synaptic spread of tauopathy and degeneration of their constituent neuronal cell bodies. To identify molecular correlates of resistance, we derived and implemented a ratio of ratios approach... Читать дальше...
by Sidaswar Krishnan, Matthew Z. DeMaere, Dominik Beck, Martin Ostrowski, Justin R. Seymour, Aaron E. Darling
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by Kiichiro Taniguchi, Tatsushi Igaki
The function of the stem cell system is supported by a stereotypical shape of the niche structure. In Drosophila ovarian germarium, somatic cap cells form a dish-like niche structure that allows only two or three germ-line stem cells (GSCs) reside in the niche. Despite extensive studies on the mechanism of stem cell maintenance, the mechanisms of how the dish-like niche structure is shaped and how this structure contributes to the stem cell system have been elusive. Читать дальше...
by The PLOS Genetics Editors
by Arthur Bernard, Steffen Wischmann, Dario Floreano, Laurent Keller
Displaced communication, whereby individuals communicate regarding a subject that is not immediately present (spatially or temporally), is one of the key features of human language. It also occurs in a few animal species, most notably the honeybee, where the waggle dance is used to communicate the location and quality of a patch of flowers. However, it is difficult to study how it emerged given the paucity of species displaying... Читать дальше...
by William T. Harvey, Vinny Davies, Rodney S. Daniels, Lynne Whittaker, Victoria Gregory, Alan J. Hay, Dirk Husmeier, John W. McCauley, Richard Reeve
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by Zhe Li, Josue Ortega Caro, Evgenia Rusak, Wieland Brendel, Matthias Bethge, Fabio Anselmi, Ankit B. Patel, Andreas S. Tolias, Xaq Pitkow
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by Brennica Marlow, Georg Kuenze, Jens Meiler, Julia Koehler Leman
Lipid molecules such as cholesterol interact with the surface of integral membrane proteins (IMP) in a mode different from drug-like molecules in a protein binding pocket. These differences are due to the lipid molecule’s shape, the membrane’s hydrophobic environment, and the lipid’s orientation in the membrane. We can use the recent increase in experimental structures in complex with cholesterol to understand protein-cholesterol interactions. Читать дальше...
by Elias Ventre, Ulysse Herbach, Thibault Espinasse, Gérard Benoit, Olivier Gandrillon
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by Benjamin J. Heil, Jake Crawford, Casey S. Greene
Those building predictive models from transcriptomic data are faced with two conflicting perspectives. The first, based on the inherent high dimensionality of biological systems, supposes that complex non-linear models such as neural networks will better match complex biological systems. The second, imagining that complex systems will still be well predicted by simple dividing lines prefers linear models that are easier to interpret. We... Читать дальше...
by Joshua A. Bull, Helen M. Byrne
We introduce a new spatial statistic, the weighted pair correlation function (wPCF). The wPCF extends the existing pair correlation function (PCF) and cross-PCF to describe spatial relationships between points marked with combinations of discrete and continuous labels. We validate its use through application to a new agent-based model (ABM) which simulates interactions between macrophages and tumour cells. These interactions are influenced by the spatial... Читать дальше...
by Weiqi Lu, José N. Onuchic, Michele Di Pierro
A model for DNA and nucleosomes is introduced with the goal of studying chromosomes from a single base level all the way to higher-order chromatin structures. This model, dubbed the Widely Editable Chromatin Model (WEChroM), reproduces the complex mechanics of the double helix including its bending persistence length and twisting persistence length, and their respective temperature dependence. The WEChroM Hamiltonian is composed of chain connectivity... Читать дальше...
by Peter J. Ralph, Mathieu Pernice
We can use photosynthesis to capture carbon and make industries greener. Algae-driven carbon capture and manufacturing offer the potential for reducing CO2 emissions while also producing commodities such as bioplastics.