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2023

Новости за 26.04.2023

Blast from the past

Red Bull X-Alps 

Andy Frötscher is a legend of the Red Bull X-Alps and took part in every edition between 2003 and 2013. He was scheduled to return as supporter to Lukas Hofer. Sadly Hofer has had to pull out, but we caught up with Andy anyhow to hear his epic tales and why he hasn’t ruled out returning again one day.

Montibeller Coffee Shop / Térreo Arquitetos

Archdaily.com 

The program of the coffee shop is given by the set of products offered to customers, quick service for personalized coffees and preparation of meals served on site. Therefore, the main challenge was to articulate the functionality of equipment, food handling, finishing of dishes, service counter, and space for tables and chairs for customers in a small space (25m²). Additionally, it was crucial to have direct customer service contact with the public space.



Twitter mobility dynamics during the COVID-19 pandemic: A case study of London

Plos.org 

by Chen Zhong, Robin Morphet, Mitsuo Yoshida

The current COVID-19 pandemic has profoundly impacted people’s lifestyles and travel behaviours, which may persist post-pandemic. An effective monitoring tool that allows us to track the level of change is vital for controlling viral transmission, predicting travel and activity demand and, in the long term, for economic recovery. In this paper, we propose a set of Twitter mobility indices to explore and visualise changes in people’s travel and activity patterns... Читать дальше...

The clinical features of familial focal epilepsy with variable foci and NPRL3 gene variant

Plos.org 

by Yue Wang, Peimin Yu, Guoxing Zhu, Xunyi Wu, Ding Ding, Zhen Hong

Objective

Familial focal epilepsy with variable foci (FFEVF) is a rare type of focal epilepsy syndrome; it is associated with NPRL3 variant. However, relevant reports are rare in China. We aimed to analyze the clinical features of Chinese patients with FFEVF to understand further the differences between various NPRL3 variants and explored the effect of NPRL3 variant on mRNA.

Methods

We ran a full workup on a family with FFEVF (four patients... Читать дальше...

The leaky pipeline of diverse race and ethnicity representation in academic science and technology training in the United States, 2003–2019

Plos.org 

by Ashish Sarraju, Summer Ngo, Fatima Rodriguez

Introduction

Diverse race and ethnicity representation remains lacking in science and technology (S&T) careers in the United States (US). Due to systematic barriers across S&T training stages, there may be sequential loss of diverse representation leading to low representation, often conceptualized as a leaky pipeline. We aimed to quantify the contemporary leaky pipeline of S&T training in the US.

Methods

We analyzed US S&T degree data... Читать дальше...

Regulation of the two-pore domain potassium channel, THIK-1 and THIK-2, by G protein coupled receptors

Plos.org 

by Michihiro Tateyama, Yoshihiro Kubo

A member of THIK (two pore domain halothane-inhibited K+) channels, THIK-1, was reported as a target of Gi/o-coupled receptors (Gi/o-Rs) in neurons and microglia. We confirmed that in HEK293T cells the THIK-1 channel is activated by Gi/o-Rs and found that Gq-coupled receptors (Gq-Rs) also activates the channel. The effects of Gi/o-Rs and Gq-Rs were inhibited by the Gi/o inhibitor pertussis toxin and phospholipase C (PLC) inhibitor, respectively. The effects... Читать дальше...

A neutral comparative analysis of additive, multiplicative, and mixed quantitative randomized response models

Plos.org 

by Muhammad Azeem, Sidra Ali

In survey sampling, the randomized response technique is a useful tool to collect reliable data in many fields including sociology, education, economics, and psychology etc. Over the past few decades, many variants of quantitative randomized response models have been developed by researchers. The existing literature on randomized response models lacks a neutral comparative study of different models to help the practitioners choose the appropriate model for a given practical problem. Читать дальше...





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