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Nucleophilic covalent fragments against cysteine (!)

Practicalfragments.blogspot.com 

Covalent fragment-based drug discovery continues to gain momentum, as evidenced by the number of talks at the CHI Drug Discovery Chemistry meeting in April. All of those involved nucleophilic residues on proteins, especially cysteine, reacting with electrophilic fragments. However, as we noted last year, it is possible to do the reverse. This is the topic of a new paper in Nat. Chem. Biol. by Jing Yang (Beijing Institute of Lifeomics), Kate Carroll (UF Scripps), and collaborators.

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Tropical Depression 3 has formed in the Atlantic and should be a hurricane this week - Miami Herald

Google.com 

  1. Tropical Depression 3 has formed in the Atlantic and should be a hurricane this week  Miami Herald
  2. Sunday tropical update: Depression could form soon in Atlantic  WWLTV
  3. 'Near 100%' chance tropical wave develops into depression within 48 hours, NHC says  WFLA News Channel 8
  4. Atlantic Shows Early Signs of Busy Storm Season: Weather Watch  Bloomberg
  5. View Full Coverage on Google News

Kris Jenner congratulates daughter Kourtney on pregnancy: 'I love you so much!' - USA TODAY

Google.com 

  1. Kris Jenner congratulates daughter Kourtney on pregnancy: 'I love you so much!'  USA TODAY
  2. Travis Barker's Ex & Kim Kardashian React to Kourtney's Pregnancy | E! News  E! News
  3. How Scott Disick Feels About Kourtney Kardashian and Travis Barker's Baby News  Yahoo Life
  4. Kris Jenner Celebrates Daughter Kourtney Kardashian's Pregnancy News  PEOPLE
  5. How Shanna Moakler Reacted After Learning Ex Travis Barker Is Expecting Baby With Kourtney Kardashian  E! NEWS
  6. View... Читать дальше...





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