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2023

Новости за 02.08.2023

How stra(i)nge are your controls? A comparative analysis of metabolic phenotypes in commonly used C57BL/6 substrains

Plos.org 

by Annesha Sil, Marina Souza Matos, Mirela Delibegovic, Bettina Platt

In recent years, insufficiently characterised controls have been a contributing factor to irreproducibility in biomedical research including neuroscience and metabolism. There is now a growing awareness of phenotypic differences between the C57BL/6 substrains which are commonly used as control animals. We here investigated baseline metabolic characteristics such as glucose regulation, fasted serum insulin levels and hepatic... Читать дальше...



Quantile regression for static panel data models with time-invariant regressors

Plos.org 

by Li Tao, Lingnan Tai, Maozai Tian

This paper proposes two new weighted quantile regression estimators for static panel data model with time-invariant regressors. The two new estimators can improve the estimation of the coefficients with time-invariant regressors, which are computationally convenient and simple to implement. Also, the paper shows consistency and asymptotic normality of the two proposed estimator for sequential and simultaneous N, T asymptotics. Monte Carlo simulation in... Читать дальше...

Sniffer worm, C. elegans, as a toxicity evaluation model organism with sensing and locomotion abilities

Plos.org 

by Jun Sung Kim, Sang-Kyu Park, Haeshin Lee

Additive manufacturing, or 3D printing, has revolutionized the way we create objects. However, its layer-by-layer process may lead to an increased incidence of local defects compared to traditional casting-based methods. Factors such as light intensity, depth of light penetration, component inhomogeneity, and fluctuations in nozzle temperature all contribute to defect formations. These defective regions can become sources of toxic component leakage... Читать дальше...

Changes in the prevalence of dementia in Australia and its association with geographic remoteness

Plos.org 

by Rezwanul Haque, Khorshed Alam, Jeff Gow, Christine Neville

Background

The exact prevalence of dementia in Australia is ambiguous. Australia is a vast continent with a small population, and 80% of the population live in five cities. This study explores recent changes in the prevalence of dementia. It also investigates geographic remoteness as a potential risk factor for developing dementia.

Methods

Survey of Disability, Ageing and Carers (SDAC), a nationally representative database, was used to conduct this study. Читать дальше...

‘Dreaming Whilst Black’: Showtime Acquires Buzzy BBC Comedy From Big Deal Films & A24

Deadline.com 

EXCLUSIVE: Showtime has picked up the BBC’s BAFTA-winning buzzy breakout comedy Dreaming Whilst Black from Big Deal Films and A24. The move is the latest step in the show’s ascent, having started life as a web series before moving to BBC pilot, then series and subsequently being picked up by A24 for distribution in the […]

Could The LK-99 Superconductor Herald The Next Technological Age?

Oilprice.com 

There has been a lot of excitement on social media about the claim of a new superconductor that works at room temperature but also under ambient pressure. If the claims are true, the world could be nearing a new type of superconductor that some experts liken to the invention of the transistor.  Last month, South Korean researchers published two new papers on what they say is a groundbreaking achievement: the development of a superconductor that operates at room temperature and standard atmospheric pressure. Читать дальше...

Don’t Panic, But Leprosy Might Be Endemic in Florida Now

Lifehacker.com 

Leprosy is probably best known as the disease that made people “unclean” in Biblical times, so it may seem surprising that the CDC published a report this week suggesting that the disease may be spreading under the radar in Florida. But don’t flee in terror, because we’re going to discuss what the report means—and…

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The 2023 Nissan Z Reminds Us That Cheap Thrills Are Timeless

Jalopnik.com 

First things first: This is a review of the Nissan Z. It is not a review of any of the sports cars one might cross-shop with a Nissan Z. In this realm, the Z is no hatchet to anyone’s scalpel; no flip phone, no fullback. This is a story about the Z, and how I felt driving it. To my friend’s house in North Jersey. To…

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