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2023

Новости за 04.08.2023

Association of cyclooxygenase-2 expression with endoplasmic reticulum stress and autophagy in triple-negative breast cancer

Plos.org 

by Haechan Lee, SungWook Jung, Gyungyub Gong, Bora Lim, Hee Jin Lee

Cyclooxygenase-2 plays a role in oncogenesis and its overexpression is associated with triple-negative breast cancer. However, the mechanisms whereby cyclooxygenase-2 contribute to breast cancer are complex and not well understood. Cyclooxygenase-2 overexpression causes hypoxia, oxidative stress, and endoplasmic reticulum stress. The aim of this study is to investigate the correlations among cyclooxygenase-2 expression, endoplasmic reticulum stress-associated molecules... Читать дальше...

Norms in action? On the channels through which Poland’s historical partitions may still contribute to divergent educational achievements in the country’s regions

Plos.org 

by Mikołaj Herbst

The goal of this paper is to better understand the importance of a long-erased border between two empires that once partitioned Poland and its ongoing effect on regional educational achievement. Previous research has indicated that inherited norms towards education may explain the observed gap in the achievement of students in the former Austrian and Russian partitions of Poland. Findings suggest that although a gap in favour of the former Austrian partition does indeed exist in four school subjects... Читать дальше...



Chinese yuan interest rate swap yields

Plos.org 

by Tanweer Akram, Khawaja Mamun

This paper models the dynamics of Chinese yuan–denominated long-term interest rate swap yields. It shows that the short-term interest rate exerts a decisive influence on the long-term swap yield after controlling for various macrofinancial variables, such as core inflation, the growth of industrial production, the percent change in the equity price index, and the percentage change in the Chinese yuan exchange rate. The autoregressive distributed lag approach... Читать дальше...

The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study

Plos.org 

by Xue-Fei Liu, Jing-Jing Lu, Ying Li, Xiu-Ying Yang, Jin-Wei Qiang

This study was to investigate the effects of ammonia and manganese in the metabolism of minimal hepatic encephalopathy (MHE). A total of 32 Sprague-Dawley rats were divided into four subgroups: chronic hyperammonemia (CHA), chronic hypermanganese (CHM), MHE and control group (CON). 1H-NMR-based metabolomics was used to detect the metabolic changes. Sparse projection to latent structures discriminant analysis was used for identifying and comparing the key metabolites. Читать дальше...

Photoacoustic and absorption spectroscopy imaging analysis of human blood

Plos.org 

by Wei-Yun Tsai, Stephan Breimann, Tsu-Wang Shen, Dmitrij Frishman

Photoacoustic and absorption spectroscopy imaging are safe and non-invasive molecular quantification techniques, which do not utilize ionizing radiation and allow for repeated probing of samples without them being contaminated or damaged. Here we assessed the potential of these techniques for measuring biochemical parameters. We investigated the statistical association between 31 time and frequency domain features derived... Читать дальше...

Is “earth” an animate thing? Cross-language and inter-age analyses of animacy word ratings in European Portuguese and British English young and older adults

Plos.org 

by Sara B. Félix, Marie Poirier, Josefa N. S. Pandeirada

Animacy plays an important role in cognition (e.g., memory and language). Across languages, a processing advantage for animate words (representing living beings), comparatively to inanimate words (i.e., non-living things), has been found mostly in young adults. Evidence in older adults, though, is still unclear, possibly due to the use of stimuli not properly characterised for this age group. Indeed, whereas several animacy word-rating studies already exist for young adults... Читать дальше...

Immunogenic mapping of rDyn-1 and rKDDR-plus proteins and selection of oligopeptides by immunoblotting for the diagnosis of Leishmania infantum-infected dogs

Plos.org 

by Williane Fernanda Siqueira, Mariana Santos Cardoso, Vanessa Gomes Fraga, Jennifer Ottino, Vitor Márcio Ribeiro, Carolina Novato Gondim, Joziana Muniz de Paiva Barçante, Ana Carolina Amado Gomes, Alexsandro Sobreira Galdino, Kasper Eersels, Bart van Grinsven, Daniella Castanheira Bartholomeu, Lilian Lacerda Bueno, Thomas Cleij, Ricardo Toshio Fujiwara

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Emergence of linkage between cooperative RNA replicators encoding replication and metabolic enzymes through experimental evolution

Plos.org 

by Kensuke Ueda, Ryo Mizuuchi, Norikazu Ichihashi

The integration of individually replicating genes into a primitive chromosome is a key evolutionary transition in the development of life, allowing the simultaneous inheritance of genes. However, how this transition occurred is unclear because the extended size of primitive chromosomes replicate slower than unlinked genes. Theoretical studies have suggested that a primitive chromosome can evolve in the presence of cell-like compartments, as... Читать дальше...





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