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Новости за 04.08.2023

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The σB alternative sigma factor circuit modulates noise to generate different types of pulsing dynamics

Plos.org 
En

by Torkel E. Loman, James C. W. Locke

Single-cell approaches are revealing a high degree of heterogeneity, or noise, in gene expression in isogenic bacteria. How gene circuits modulate this noise in gene expression to generate robust output dynamics is unclear. Here we use the Bacillus subtilis alternative sigma factor σB as a model system for understanding the role of noise in generating circuit output dynamics. σB controls the general stress response in B. subtilis and is activated by a range of energy and environmental stresses. Читать дальше...

Species-specific wiring of cortical circuits for small-world networks in the primary visual cortex

Plos.org 
En

by Seungdae Baek, Youngjin Park, Se-Bum Paik

Long-range horizontal connections (LRCs) are conspicuous anatomical structures in the primary visual cortex (V1) of mammals, yet their detailed functions in relation to visual processing are not fully understood. Here, we show that LRCs are key components to organize a “small-world network” optimized for each size of the visual cortex, enabling the cost-efficient integration of visual information. Using computational simulations of a biologically inspired model neural network... Читать дальше...

Авторские публикации Smi24.net

FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells

Plos.org 
En

by Seon Hye E. Park, Ashwinikumar Kulkarni, Genevieve Konopka

During cortical development, human basal radial glial cells (bRGCs) are highly capable of sustained self-renewal and neurogenesis. Selective pressures on this cell type may have contributed to the evolution of the human neocortex, leading to an increase in cortical size. bRGCs have enriched expression for Forkhead Box P1 (FOXP1), a transcription factor implicated in neurodevelopmental disorders (NDDs) such as autism spectrum disorder. Читать дальше...

Mariners Moose Tracks, 8/4/23: J.P. Crawford, Eduardo Rodríguez, and Domingo Germán

Lookout Landing 
En

Gary A. Vasquez-USA TODAY Sports

The Mariners are rolling!

Good morning everyone! Let’s check out what’s happening around baseball.

In Mariners news...

  • Watch it again, in all of its glory.

Cade Marlowe was a 20th round pick in 2019 who received a $5,000 signing bonus as a senior out of Division-II West Georgia, where he hit just 12 HR in 184 games

now he's hitting go-ahead 9th inning grand slams off 100 MPH heaters in the big leaguespic.twitter.com/10f0iB5BVp

... Читать дальше...



Elephant Rumblings: Hendu’s legacy of charity and service thrives

Athletics Nation 
En

MLB news roundup

Happy Friday, Athletics Nation!

Melissa Lockard at The Athletic put out an incredible piece about former A’s outfielder Dave Henderson, and how Hendu’s family is carrying forward his legacy of joy and kindness through the Always Having Fun Foundation (AHFF), which was founded in 2017, two years after Henderson’s untimely death at the age of 57.

AHFF raises money to fund research for a cure for a rare nervous disorder known as Angelman Syndrome. It affects about half a million people worldwide... Читать дальше...

Power Book IV: Force Season 2: Release Date, Cast, Episode Count & Everything Else You Need To Know

Блог сайта «Face Tube is a fun name,» 
En

Death, taxes, and more Power may be the only absolutes in life.

The Power Universe continues to be one of the most successful television franchises currently on the air, with a trio of hit series that fans can't get enough of.

After the highly successful Power Book II: Ghost Season 3, the uber-popular Tommy Egan spinoff Power Book IV: Force is next up. And we're glad to report you don't have to wait much longer to see what Tommy is getting up to in the wild streets of Chicago. Читать дальше...

Oil Prices Are On A Six-Week Winning Streak

Oilprice.com 
En

Crude oil prices were set for yet another weekly gain after Saudi Arabia said it would extend its voluntary production cuts of 1 million bpd into September. The Kingdom added fuel to the rally by suggesting it could extend them beyond September, too, or deepen the cuts, or combined both an extension and deeper cuts. Prices got an additional boost this week from the American Petroleum Institute and the Energy Information Administration, which both estimated the most significant drawdown in U.S. oil... Читать дальше...

The Chi Premiere Recap: Emmett Is in Way Too Deep — Plus, Grade It!

TVLine.com 
En

Hope that Smokey’s glow-up was worth it, Emmett! Before The Chi‘s Season 6 premiere is over, EJ’s dad gets a firsthand lesson in how ruthless, exacting and horrifyingly violent his new business partner can be. But will a cold-blooded killing committed within feet of Emmett’s shocked face be enough for him to end his financial […]

You Can Make Boring Glass Look Like Sea Glass

Lifehacker.com 
En

If you have some clear glass decor you’re tired of, or if you found a great piece at a thrift store, but the color isn’t quite what you want, you might think the only option is to replace it. But before you do that, you have another option: You can give them a beachy makeover with sea glass paint. This spray-paint…

Читать дальше...

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Все города России
Smi24.net
Многим рискует: юрист сказал, как сидит «золотой» экс-полковник Захарченко В Москве мужчина ограбил магазин на АЗС, угрожая пистолетом Жители Прикамья активно покупают билеты на транспорт в отделениях Почты России АвтоВАЗ отгружает Lada Iskra дилерам. Цены объявят на этой неделе

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