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2023

Новости за 17.08.2023

Biomechanical analyses of different serve and groundstroke techniques in tennis: A systematic scoping review

Plos.org 

by Johanna Lambrich, Thomas Muehlbauer

This systematic scoping review aims to summarize findings regarding kinetic, kinematic, and electromyographic analyses of different characteristics (i.e., type/direction and stance style) of the tennis serve and groundstroke. A systematic search of the literature was performed on the databases PubMed, Web of Science, and SportDiscus from their inception date till May 2023. A descriptive analysis of results was conducted. The literature search identified a total of N = 899 records... Читать дальше...

Optimization design and analysis of mobile pump truck frame using response surface methodology

Plos.org 

by Liang Cheng, Hai-Bin Lin, Yu-Liang Zhang

In order to realize the lightweight design of mobile pump truck, this paper takes the frame of a certain type of mobile pump truck as the research object. The response surface method is used to carry out lightweight design of the longitudinal beam structure of the frame, and the finite element method is used to establish the finite element model to compare and analyze the optimized and original designs. The results show that the height, width and... Читать дальше...

What socio-demographic factors support disposable vs. sustainable menstrual choices? Evidence from India’s National Family Health Survey-5

Plos.org 

by Karan Babbar, Supriya Garikipati

For over a decade, improving menstrual hygiene among poor girls and women in low-and-middle-income-countries has been a prominent global goal. Towards this, governments in the Global South have worked to promote the uptake of disposable sanitary pads. Despite this, we continue to see a high prevalence of period poverty mainly because disposable pads require monthly purchasing that may be burdensome for many women. Not only are pads financially unsustainable... Читать дальше...



Effects of high intensity interval training versus moderate intensity continuous training on exercise capacity and quality of life in patients with heart failure: A systematic review and meta-analysis

Plos.org 

by Shengyuan Gu, Xinchao Du, Dongwei Wang, Yaohua Yu, Shifang Guo

Introduction and aims

High intensity interval training (HIIT) is considered as an alternative exercise modality to moderate intensity continuous training (MICT) for heart failure (HF) patients. Yet a growing number of trials demonstrated inconsistent findings about the effectiveness of HIIT versus MICT until SMARTEX study and OptimEx-Clin study have made a consistent negative conclusion that HIIT was not superior to MICT. Читать дальше...

The onchocerciasis hypothesis of nodding syndrome

Plos.org 

by Robert Colebunders, Amber Hadermann, Joseph Nelson Siewe Fodjo

Nodding syndrome (NS) is a phenotypic presentation of onchocerciasis-associated epilepsy (OAE). OAE is an important public health problem in areas with high ongoing Onchocerca volvulus transmission. OAE, including NS, is preventable by strengthening onchocerciasis elimination programs. The presence of tau in OAE postmortem brains could be the consequence of neuroinflammation directly or indirectly induced by O. volvulus. Omics research is needed to investigate whether O. Читать дальше...

Elucidation of genome-wide understudied proteins targeted by PROTAC-induced degradation using interpretable machine learning

Plos.org 

by Li Xie, Lei Xie

Proteolysis-targeting chimeras (PROTACs) are hetero-bifunctional molecules that induce the degradation of target proteins by recruiting an E3 ligase. PROTACs have the potential to inactivate disease-related genes that are considered undruggable by small molecules, making them a promising therapy for the treatment of incurable diseases. However, only a few hundred proteins have been experimentally tested for their amenability to PROTACs, and it remains unclear which other... Читать дальше...

The specious art of single-cell genomics

Plos.org 

by Tara Chari, Lior Pachter

Dimensionality reduction is standard practice for filtering noise and identifying relevant features in large-scale data analyses. In biology, single-cell genomics studies typically begin with reduction to 2 or 3 dimensions to produce “all-in-one” visuals of the data that are amenable to the human eye, and these are subsequently used for qualitative and quantitative exploratory analysis. However, there is little theoretical support for this practice, and we show that extreme dimension reduction... Читать дальше...

Target-selective vertebrate motor axon regeneration depends on interaction with glial cells at a peripheral nerve plexus

Plos.org 

by Lauren J. Walker, Camilo Guevara, Koichi Kawakami, Michael Granato

A critical step for functional recovery from peripheral nerve injury is for regenerating axons to connect with their pre-injury targets. Reestablishing pre-injury target specificity is particularly challenging for limb-innervating axons as they encounter a plexus, a network where peripheral nerves converge, axons from different nerves intermingle, and then re-sort into target-specific bundles. Here, we examine this process... Читать дальше...

Extensive topographic remapping and functional sharpening in the adult rat visual pathway upon first visual experience

Plos.org 

by Joana Carvalho, Francisca F. Fernandes, Noam Shemesh

Understanding the dynamics of stability/plasticity balances during adulthood is pivotal for learning, disease, and recovery from injury. However, the brain-wide topography of sensory remapping remains unknown. Here, using a first-of-its-kind setup for delivering patterned visual stimuli in a rodent magnetic resonance imaging (MRI) scanner, coupled with biologically inspired computational models, we noninvasively mapped brain-wide properties—receptive... Читать дальше...





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