by Elisabeth Hertenstein, Marion Kuhn, Nina Landmann, Jonathan-Gabriel Maier, Carlotta Louisa Schneider, Kristoffer Daniel Fehér, Lukas Frase, Dieter Riemann, Bernd Feige, Christoph Nissen
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by Matthew Xu, John D. Brannan, Vincent Ho, Jerry Zhou
Persistent variability observed during spirometry, even when technical and personal factors are controlled, has prompted interest in uncovering its underlying mechanisms. Notably, our prior investigations have unveiled that spirometry has the potential to trigger gastro-esophageal reflux in a susceptible population. This current study embarks on elucidating the intricate mechanisms orchestrating reflux induced by spirometry. To achieve this... Читать дальше...
by Salahaden R. Sultan, Mohammed Khayat, Bander Almutairi, Abdulhamid Marzouq, Ahmad Albngali, Rawan Abdeen, Adnan A.S. Alahmadi, Fadi Toonsi
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by Micaela White, Lauren Hisatomi, Alex Villegas, Dagoberto Pina, Alec Garfinkel, Garima Agrawal, Nisha Punatar, Barton L. Wise, Polly Teng, Hai Le
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by Pradeep Kumar, Shobhit Srivastava, Pratishtha Chaudhary, T. Muhammad
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by Lijie Yu, Mengying Cui, Shian Dai
The station-level ridership during the peak hour is one of the key indicators for the design of station size and relevant facilities. However, with the operation of metro system, it cannot be ignored that, in many cities, the station peak and the city peak may not be simultaneously occurred. As the current ridership forecasting methods use the city peak as the point of reference, stations with wide differences of ridership in between would experience disorders... Читать дальше...
by Melash Belachew Asresie, Gizachew Worku Dagnew, Yibeltal Alemu Bekele
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by Grace E. Murray, Daniel J. Norton
Research supports abnormal inhibitory visual motion processing in adults with remitted and current depression, but all studies to date have used paradigms with simple grating stimuli. Global motion processing, where multiple motion signals must be integrated, has not been explored in depression, nor have inhibitory processes within that domain. Depressed participants (n = 46) and healthy controls (n = 28) completed a direction discrimination task featuring a random dot pattern stimulus. Читать дальше...
by Justin Nicholas, Sai Lata De, Pongsakorn Thawornpan, Awtum M. Brashear, Surendra Kumar Kolli, Pradeep Annamalai Subramani, Samantha J. Barnes, Liwang Cui, Patchanee Chootong, Francis Babila Ntumngia, John H. Adams
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by Klára Janečková, Christian Roos, Pavla Fedrová, Nikola Tom, Darina Čejková, Simone Lueert, Julius D. Keyyu, Idrissa S. Chuma, Sascha Knauf, David Šmajs
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by Abigail DiVito Evans, Regina A. Fairbanks, Paul Schmidt, Mia T. Levine
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by Jiacheng Wang, Yaojia Chen, Quan Zou
The gene regulatory structure of cells involves not only the regulatory relationship between two genes, but also the cooperative associations of multiple genes. However, most gene regulatory network inference methods for single cell only focus on and infer the regulatory relationships of pairs of genes, ignoring the global regulatory structure which is crucial to identify the regulations in the complex biological systems. Here, we proposed a graph-based... Читать дальше...
by Adrian L. Hauber, Marcus Rosenblatt, Jens Timmer
Ordinary differential equations are frequently employed for mathematical modeling of biological systems. The identification of mechanisms that are specific to certain cell types is crucial for building useful models and to gain insights into the underlying biological processes. Regularization techniques have been proposed and applied to identify mechanisms specific to two cell types, e.g., healthy and cancer cells, including the LASSO (least absolute shrinkage and selection operator). Читать дальше...
by Tyler T. Cooper, Lynne-Marie Postovit
The mechanistic underpinnings of breast cancer recurrence following periods of dormancy are largely undetermined. A new study in PLOS Biology reveals that docetaxel-induced injury of tumour stromal cells stimulates the release of cytokines that support dormancy escape of breast cancer cells. The mechanistic underpinnings of breast cancer recurrence following periods of dormancy are largely undetermined. This Primer explores a new study in PLOS Biology... Читать дальше...By Erik Barnes Published: September 13th, 2023
Learn how to set up Enhanced Conversions, move to a smart bidding strategy and set targets ROAS and target bids.
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Photo by John Fisher/Getty Images
Are things finally turning a corner in Queens?
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MLB news roundup
Happy Wednesday, Athletics Nation!
Last year, the rebuilding Oakland A’s traded top starting pitcher Frankie Montas to the Yankees, with the briefly brilliant reliever Lou Trivino riding sidecar alongside Montas to New York City. Sadly, neither Frankie nor Lou has pitched in 2023.
In return, the A’s got pitching prospects Ken Waldichuk, JP Sears, and Luis Medina along with second baseman Cooper Bowman. Now, the three... Читать дальше...
Many Republican county chairs are open to a Trump alternative.
The state's Democratic Party chair is organizing youth and rural voters, and people have noticed: “They know she’s fighting for them.”
Tito Ortiz | Photo by Eric Espada/Getty Images
Dana White has had his fair share of public feuds, but few have rankled him more than Tito Ortiz and Randy Couture.
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The playwright’s exquisite new comic drama, “Infinite Life,” nails the absurdity of having a body.
All eleven authors are being honored by the National Book Awards for the first time.