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Новости за 16.10.2023



The RgaS-RgaR two-component system promotes Clostridioides difficile sporulation through a small RNA and the Agr1 system

Plos.org 

by Adrianne N. Edwards, Shonna M. McBride

The ability to form a dormant spore is essential for the survival of the anaerobic pathogen, Clostridioides difficile, outside of the mammalian gastrointestinal tract. The initiation of sporulation is governed by the master regulator of sporulation, Spo0A, which is activated by phosphorylation. Multiple sporulation factors control Spo0A phosphorylation; however, this regulatory pathway is not well defined in C. difficile. We discovered that RgaS and RgaR... Читать дальше...

Batch normalization followed by merging is powerful for phenotype prediction integrating multiple heterogeneous studies

Plos.org 

by Yilin Gao, Fengzhu Sun

Heterogeneity in different genomic studies compromises the performance of machine learning models in cross-study phenotype predictions. Overcoming heterogeneity when incorporating different studies in terms of phenotype prediction is a challenging and critical step for developing machine learning algorithms with reproducible prediction performance on independent datasets. We investigated the best approaches to integrate different studies of the same type of omics... Читать дальше...

Pleiotropic hubs drive bacterial surface competition through parallel changes in colony composition and expansion

Plos.org 

by Jordi van Gestel, Andreas Wagner, Martin Ackermann

Bacteria commonly adhere to surfaces where they compete for both space and resources. Despite the importance of surface growth, it remains largely elusive how bacteria evolve on surfaces. We previously performed an evolution experiment where we evolved distinct Bacilli populations under a selective regime that favored colony spreading. In just a few weeks, colonies of Bacillus subtilis showed strongly advanced expansion rates, increasing... Читать дальше...

Satellites watch the annular solar eclipse 2023 sweep over the U.S. (video) - Space.com

Google.com 

  1. Satellites watch the annular solar eclipse 2023 sweep over the U.S. (video)  Space.com
  2. The Most Captivating Photos of This Weekend's Annular Eclipse  Gizmodo
  3. Amarillo witnesses annular solar eclipse in the early Oct. 14 sky  Amarillo Globe-News
  4. Total solar eclipse April 2024: 8 top tips for planning your trip  Space.com
  5. Solar eclipse stuns crowds in Americas  Reuters
  6. View Full Coverage on Google News





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