Real world treatment sequences and outcomes for metastatic renal cell carcinoma
by Gu-Shun Lai, Jian-Ri Li, Shian-Shiang Wang, Chuan-Shu Chen, Chun-Kuang Yang, Chia-Yen Lin, Sheng-Chun Hung, Kun-Yuan Chiu, Shun-Fa Yang
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by Gu-Shun Lai, Jian-Ri Li, Shian-Shiang Wang, Chuan-Shu Chen, Chun-Kuang Yang, Chia-Yen Lin, Sheng-Chun Hung, Kun-Yuan Chiu, Shun-Fa Yang
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by Gary Mallach, Liu (Sunny) Sun, Michael McKay, Thomas Kovesi, Gail Lawlor, Ryan Kulka, J. David Miller
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by Erin K. Howie, Kristi L. Perryman, Joseph Moretta, Laura Cameron
BackgroundRecess provides a key physical activity opportunity for students in school, yet a wide range of recess requirements exist. To design optimal recess policies, the effect of recess on students’ educational outcomes must be better understood. Therefore, the purpose of this mixed-method systematic review is to identify and systematically evaluate research on the effects of recess on student educational outcomes, including behavior... Читать дальше...
by Paul H. Zedler, Bradley M. Herrick
Climate change is likely to imperil native biodiversity through the increased frequency of extreme events. Here we address the short-term effects of an extreme flooding event on an unplowed prairie reserve, the Faville Prairie Wisconsin State Natural Area. This 25-ha property is a remnant of the formerly extensive Crawfish Prairie that lay on the east bank of the Crawfish River, Jefferson County, Wisconsin USA. The Faville remnant has historically been... Читать дальше...
by Jorieke Deschrevel, Karen Maes, Anke Andries, Nathalie De Beukelaer, Marlies Corvelyn, Domiziana Costamagna, Anja Van Campenhout, Eva De Wachter, Kaat Desloovere, Anouk Agten, Frank Vandenabeele, Stefaan Nijs, Ghislaine Gayan-Ramirez
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by André Daher, Júlio Castro-Alves, Leandro Amparo, Natalia Pacheco de Moraes, Thaís Regina Araújo dos Santos, Karla Regina Gram dos Santos, Cristiane Siqueira do Valle, Maria Hermoso, Margareth Catoia Varela, Rodrigo Correa Oliveira
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by Sara Belligoni, Kelly A. Stevens, Samiul Hasan, Haofei Yu
People continue to use technology in new ways, and how governments harness digital information should consider privacy and security concerns. During COVID19, numerous countries deployed digital contact tracing that collect location data from user’s smartphones. However, these apps had low adoption rates and faced opposition. We launched an interdisciplinary study to evaluate smartphone location data concerns among college students in the US. Читать дальше...
by Laurie Simard, Julie Bouchard, Martin Lavallière, Tommy Chevrette
This article discussed the issue of low PA levels among school-aged children and highlights the promising approach of school-based interventions, including physically active learning (PAL), to increase PA levels. The study aimed to co-design and to assess the implementation of a PAL program for 8 weeks in 4 elementary classrooms (82 students and 7 teachers), emphasizing the potential of integrating PA with academic learning... Читать дальше...
by Choungwon Jung, Soyoung Park, Hyunah Kim
Nonalcoholic fatty liver disease (NAFLD) is a growing health concern with increasing prevalence and associated health impacts. Although no approved drugs are available for the NAFLD treatment, several hypoglycemic agents have been investigated as promising therapeutic agents. We aimed to compare the risk of occurrence of NAFLD with respect to the use of different hypoglycemic agents in patients with type 2 diabetes. This retrospective cohort study... Читать дальше...
by Denis K. Byarugaba, Bernard Erima, Godfrey Wokorach, Stephen Alafi, Hannah Kibuuka, Edison Mworozi, Ambrose K. Musinguzi, James Kiyengo, Florence Najjuka, Fred Wabwire-Mangen
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by Eduardo Encina, Worawalan Waratworawan, Yamol Kongjareon, Mayur M. Desai, Thomas E. Guadamuz
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by Minghui Ma, Lei Song, Yabin Jia, Zongxiao Yang
Wind power systems are a promising form of energy supply. At present, most of the studies focuses on the performance of individual components such as wind rotors or generators, and the overall output effect of wind power system is determined by the characteristics of wind rotor and generator and their combined characteristics. However, the evaluation of the overall output characteristics of the system is rarely considered. In order to investigate the overall output of the system quickly... Читать дальше...
by Shana Kushner Gadarian, Logan Strother
How does the public assess the Supreme Court and its work? Using data from three surveys conducted over a span of ten years, we show that individuals’ policy preferences drive evaluations of the Court and its willingness to reform the Court. We find strong evidence that the Court’s hybrid legal-political nature enables a unique form of policy-motivated reasoning: respondents who agree with Court outputs view the Court and its work as more “legal” in nature... Читать дальше...
by Minami Shichinohe, Shun Ohkawa, Yuu Hirose, Toshihiko Eki
Mutagens and oxidative agents damage biomolecules, such as DNA; therefore, detecting genotoxic and oxidative chemicals is crucial for maintaining human health. To address this, we have developed several types of yeast-based reporter assays designed to detect DNA damage and oxidative stress. This study aimed to develop a novel yeast-based assay using a codon-optimized stable or unstable NanoLuc luciferase (yNluc and yNluCP) gene... Читать дальше...
by Noor Al Khathlan
BackgroundThe World Health Organization (WHO) reported that the prevalence of obesity in the Kingdom of Saudi Arabia (KSA) is 33.7% (women 39.5% and men 29.5%), respectively. The effects of obesity on airway inflammation and respiratory mechanics as well as the function of adipose tissue has a key role in the development of various lung diseases. Therefore, this study aimed to compare the level of cytokines between obese (BMI ≥ 30) and non-obese participants and to assess their association with BMI... Читать дальше...
by Samina Ali, Claudia Maki, Asa Rahimi, Keon Ma, Maryna Yaskina, Helen Wong, Antonia Stang, Tania Principi, Naveen Poonai, Serge Gouin, Sylvia Froese R. N., Paul Clerc, Redjana Carciumaru, Waleed Alqurashi, Manasi Rajagopal, Elise Kammerer, Julie Leung, Bruce Wright, Shannon D. Scott, on behalf of the Pediatric Emergency Research Canada Family Needs Study Group
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by Julia Reddy, Kristel Black, Keia Bazemore, Kiva Jordan, Jamie B. Jackson, Andrea K. Knittel
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by Ajaya Basnet, Basanta Tamang, Mahendra Raj Shrestha, Lok Bahadur Shrestha, Junu Richhinbung Rai, Rajendra Maharjan, Sushila Dahal, Pradip Shrestha, Shiba Kumar Rai
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by Nataliya Rybnikova, Dani Broitman, Murielle Mary-Krause, Maria Melchior, Yakov Ben-Haim
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by Auttawit Sirichoat, Orawee Kaewprasert, Yothin Hinwan, Kiatichai Faksri
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by Abarna Nadeshkumar, Gitanjali Sathiadas, Shalini Sri Ranganathan
IntroductionOral liquid dosage forms remain popular in several middle income countries. The accuracy of liquid dosage form dosing depends on the accuracy and availability of measuring devices. Lack of quality oral liquid measuring devices will lead to medication errors. Hence there is an urgent need to describe the quality of manufacturer supplied measuring devices enclosed with paediatric oral liquid dosage forms currently registered in Sri Lanka. Читать дальше...
by Jordi Olivella Nadal, Gema Calleja Sanz, Ignacio Fuentes Ribas, Pedro Rodriguez Mondelo
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by Frederick P. Rivara, Ashley B. Hink, Deborah Kuhls, Samantha Banks, Lauren L. Agoubi, Shelbie Kirkendoll, Alex Winchester, Christopher Hoeft, Bhavin Patel, Avery Nathens
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by Vishesh L. Diengdoh, Barry W. Brook, Mark Hunt, Stefania Ondei
Pollinators are threatened by land-use and land-cover changes, with the magnitude of the threat depending on the pollinating taxa, land-use type and intensity, the amount of natural habitat remaining, and the ecosystem considered. This study aims to determine the effect of land use (protected areas, plantations, pastures), land cover (percentage of forest and open areas within buffers of different sizes), and plant genera on... Читать дальше...
by Oliver F. W. Gardner, Yadan Zhang, Ilyas M. Khan
Reconstruction of the outer ear currently requires harvesting of cartilage from the posterior of the auricle or ribs leading to pain and donor site morbidity. An alternative source for auricular reconstruction is in vitro tissue engineered cartilage using stem/progenitor cells. Several candidate cell-types have been studied with tissue-specific auricular cartilage progenitor cells (AuCPC) of particular interest. Whilst chondrogenic differentiation... Читать дальше...