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2023

Новости за 19.12.2023

Statistical prediction of microbial metabolic traits from genomes

Plos.org 

by Zeqian Li, Ahmed Selim, Seppe Kuehn

The metabolic activity of microbial communities is central to their role in biogeochemical cycles, human health, and biotechnology. Despite the abundance of sequencing data characterizing these consortia, it remains a serious challenge to predict microbial metabolic traits from sequencing data alone. Here we culture 96 bacterial isolates individually and assay their ability to grow on 10 distinct compounds as a sole carbon source. Using these data as well as two existing datasets... Читать дальше...

Novel metrics reveal new structure and unappreciated heterogeneity in Caenorhabditis elegans development

Plos.org 

by Gunalan Natesan, Timothy Hamilton, Eric J. Deeds, Pavak K. Shah

High throughput experimental approaches are increasingly allowing for the quantitative description of cellular and organismal phenotypes. Distilling these large volumes of complex data into meaningful measures that can drive biological insight remains a central challenge. In the quantitative study of development, for instance, one can resolve phenotypic measures for single cells onto their lineage history, enabling joint consideration... Читать дальше...

Mathematical modeling of intratumoral immunotherapy yields strategies to improve the treatment outcomes

Plos.org 

by Constantinos Harkos, Triantafyllos Stylianopoulos, Rakesh K. Jain

Intratumoral injection of immunotherapy aims to maximize its activity within the tumor. However, cytokines are cleared via tumor vessels and escape from the tumor periphery into the host-tissue, reducing efficacy and causing toxicity. Thus, understanding the determinants of the tumor and immune response to intratumoral immunotherapy should lead to better treatment outcomes. In this study, we developed a mechanistic mathematical... Читать дальше...

Pituitary-immune bidirectional crosstalk under systemic inflammation

Plos.org 

by Qingyun Li

The pituitary gland responds to and modulates immune stress through the hypothalamus–pituitary–adrenal axis. A new study in PLOS Biology reveals unconventional bidirectional communication between hormone-producing cells and the immune system upon systemic inflammation.



If she flew to Dignitas I'd want to ground the plane, says Esther Rantzen's daughter - The Times

Top Stories (uk) - Google News (com) 

  1. If she flew to Dignitas I'd want to ground the plane, says Esther Rantzen's daughter  The Times
  2. Bravo, Esther Rantzen, it’s only the wimps in Westminster who are too afraid to talk about assisted dying  The Guardian
  3. Esther Rantzen's daughter would 'ground her plane' if she decided to fly to Dignitas  The Telegraph
  4. Dame Esther Rantzen says she has joined Dignitas  Sky News

Free Throw Artistry

Duke Basketball Report 

WASHINGTON - JANUARY 21: J.J. Redick #4 of the Duke Blue Devils shoots a free throw in a game against the Georgetown Hoyas on January 21, 2006 at MCI Center in Washington D.C.. Georgetown won the game 87-84. | Photo by Mitchell Layton/Getty Images

JJ Redick is on the top of this heap but two current ACC players are in the Top Ten.

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Buffer scheduling feature added to ERP software

Canadianmetalworking.com 

Cetec ERP’s new scheduling feature allows users to estimate static buffer time occurring before or after work is completed at a given work location.

Brave Commerce Podcast: Unleashing Petco’s Tail of Success

Adweek.com 

On this episode of Brave Commerce, Darren MacDonald, chief customer officer at Petco, joins hosts Rachel Tipograph and Sarah Hofstetter to offer his perspective from the retailer side of the pet care business. MacDonald introduces the timeless principles that remain unchanged in the dynamic world of retail: assortment, price and delivery. According to him, these...

10 Best TV Shows of 2023 - Rolling Stone

Google.com 

  1. 10 Best TV Shows of 2023  Rolling Stone
  2. The 15 Best TV Shows of 2023  The Atlantic
  3. The 25 Best TV Series of 2023 | TV/Streaming  Roger Ebert
  4. The 50 best TV shows of 2023: No 2 – Succession  The Guardian
  5. Best and worst TV shows that came out in 2023, ranked  Business Insider





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