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2023

Новости за 20.12.2023

Prevalence and risk factors for human leptospirosis at a hospital serving a pastoralist community, Endulen, Tanzania

Plos.org 

by Michael J. Maze, Gabriel M. Shirima, Abdul-Hamid S. Lukambagire, Rebecca F. Bodenham, Matthew P. Rubach, Shama Cash-Goldwasser, Manuela Carugati, Kate M. Thomas, Philoteus Sakasaka, Nestory Mkenda, Kathryn J. Allan, Rudovick R. Kazwala, Blandina T. Mmbaga, Joram J. Buza, Venance P. Maro, Renee L. Galloway, Daniel T. Haydon, John A. Crump, Jo E. B. Halliday

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Using mixture density networks to emulate a stochastic within-host model of Francisella tularensis infection

Plos.org 

by Jonathan Carruthers, Thomas Finnie

For stochastic models with large numbers of states, analytical techniques are often impractical, and simulations time-consuming and computationally demanding. This limitation can hinder the practical implementation of such models. In this study, we demonstrate how neural networks can be used to develop emulators for two outputs of a stochastic within-host model of Francisella tularensis infection: the dose-dependent probability of illness and the incubation period. Читать дальше...



How Merkel cells transduce mechanical stimuli: A biophysical model of Merkel cells

Plos.org 

by Fangtao Mao, Wenzhen Yang

Merkel cells combine with Aβ afferents, producing slowly adapting type 1(SA1) responses to mechanical stimuli. However, how Merkel cells transduce mechanical stimuli into neural signals to Aβ afferents is still unclear. Here we develop a biophysical model of Merkel cells for mechanical transduction by incorporating main ingredients such as Ca2+ and K+ voltage-gated channels, Piezo2 channels, internal Ca2+ stores, neurotransmitters release, and cell deformation. Читать дальше...

High CO2 adaptation mechanisms revealed in the miR156-regulated flowering time pathway

Plos.org 

by Kun Zhang, Erkang Wang, Qiong Alison Liu, Jin Wang

Elevated CO2 concentrations have been observed to accelerate flowering time in Arabidopsis through the action of a highly conserved regulatory network controlled by miR156 and miR172. However, the network’s robustness to the impact of increasing CO2 concentrations on flowering time remains poorly understood. In this study, we investigate this question by conducting a comprehensive analysis of the global landscape of network dynamics, including... Читать дальше...

2023 at PLOS Biology

Plos.org 

by The PLOS Biology Staff Editors

2023 saw many important advances in the life sciences. In this editorial, we highlight research from across the breadth of PLOS Biology’s scope.

Best Stand Mixers (2023): 5 Baking Gadgets

Wired Magazine 

Tasty bakes are easy to make with the help of the latest statement stand mixers—as are homemade pretzels, wholesome pasta, and artisan breads.

Short Conversations with Poets: Timmy Straw

MCSWEENEY’S 

The Thomas Salto, Timmy Straw’s debut collection, offers what very little poetry in our time seems to manage: work that is both overtly political and unflinchingly aesthetic. Ben Lerner, Brenda Hillman, Jay Wright, Anne Boyer, Chris Nealon are others whose work comes to mind. But Straw’s work marries politics and aesthetics in a way maybe not seen since George Oppen, and the gift of this collection is both the lyric mystery it generates and the position of moral clarity from which it operates. Читать дальше...





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