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Новости за 12.02.2024

Accounting for isoform expression increases power to identify genetic regulation of gene expression

Plos.org 

by Nathan LaPierre, Harold Pimentel

A core problem in genetics is molecular quantitative trait locus (QTL) mapping, in which genetic variants associated with changes in the molecular phenotypes are identified. One of the most-studied molecular QTL mapping problems is expression QTL (eQTL) mapping, in which the molecular phenotype is gene expression. It is common in eQTL mapping to compute gene expression by aggregating the expression levels of individual isoforms from the same gene and then... Читать дальше...

StressME: Unified computing framework of Escherichia coli metabolism, gene expression, and stress responses

Plos.org 

by Jiao Zhao, Ke Chen, Bernhard O. Palsson, Laurence Yang

Generalist microbes have adapted to a multitude of environmental stresses through their integrated stress response system. Individual stress responses have been quantified by E. coli metabolism and expression (ME) models under thermal, oxidative and acid stress, respectively. However, the systematic quantification of cross-stress & cross-talk among these stress responses remains lacking. Here, we present StressME: the unified stress response model of E. Читать дальше...

2024 Hyundai Elantra N gets an $835 price bump

Autoblog.com 

Filed under: Hyundai,Car Buying,Performance,Sedan

Continue reading 2024 Hyundai Elantra N gets an $835 price bump

2024 Hyundai Elantra N gets an $835 price bump originally appeared on Autoblog on Mon, 12 Feb 2024 09:00:00 EST. Please see our terms for use of feeds.

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What Are Your Worst Warrantied Car Repair Stories?

Jalopnik.com 

There’s peace of mind that comes with a warranty, and it can seal the deal for many potential car buyers. It’s a mark of assurance that an automaker believes its products won’t suffer any big issue, and a promise tofix the problem if it arises. However, it’s not uncommon for headaches to emerge when people actually…

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Gameday: Spurs vs Raptors, February 12

Raptors Republic 

Toronto fans get to see Victor Wembanyama up close for the first time

The post Gameday: Spurs vs Raptors, February 12 first appeared on Raptors Republic.

How to Get Internet Famous, Crushing 12 Beers at a Time

GQ.com 

Rusty Featherstone was living the dream, rating beers on TikTok by guzzling a dozen in one sitting. But now he wants to be the next Anthony Bourdain: “I know that's a big set of shoes to fill, but that's the general idea.”

Family Tours in the Kingdom of the Sick: Extending Our Stay, or the Long QT

MCSWEENEY’S 

When COVID struck Rebecca Saltzman’s family, the virus unmasked a life-changing discovery: her husband and two of their kids had genetic heart disease. The kind where people drop dead. As their healthy wife and mother, Saltzman had a new role too—guiding her family through what Susan Sontag called the Kingdom of the Sick. In this column, she’ll explore the anthropological strangeness of this new place, the mysteries of the body, and how facing death distills life into its purest form: funny, terrifying, and sublime. Читать дальше...





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