by Yicheng Gao, Zhihan Liu, Rui Cao, Yingdi Liao, Yuting Feng, Chengyuan Su, Xinmiao Guan, Rui Fang, Yingjie Deng, Wenyuan Xiang, Junchang Liu, Yuanyuan Li, Yutong Fei
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by Lauren Cobb, Erik de Muinck, Spyros Kollias, Morten Skage, Gregor D. Gilfillan, Markus A. K. Sydenham, Shuo-Wang Qiao, Bastiaan Star
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by Solveig Flatebø, Gabriella Óturai, Mikołaj Hernik
Adults infer others’ communicative intentions, or lack thereof, from various types of information. Young children may be initially limited to attributions based on a small set of ostensive signals. It is unknown when richer pragmatic inferences about communicative intentions emerge in development. We sought novel type of evidence for such inferences in 17-to-19-month-olds. We hypothesized that toddlers recognize adults’ smartphone use in... Читать дальше...
by Qian Li, Zedong Wei, Yonglun Zhang, Chongqing Zheng
On a global scale, lung cancer(LC) is the most commonly occurring form of cancer. Nonetheless, the process of screening and detecting it in its early stages presents significant challenges. Earlier research endeavors have recognized metabolites as potentially reliable biomarkers for LC. However, the majority of these studies have been limited in scope, featuring inconsistencies in terms of the relationships and levels of association observed.Moreover... Читать дальше...
by Traver J. Wright, Timothy R. Elliott, Kathleen M. Randolph, Richard B. Pyles, Brent E. Masel, Randall J. Urban, Melinda Sheffield-Moore
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by Naeem Iqbal, Nauman Sadiq, Muhammad Nadir Naqqash, Muhammad Usman, Hafiz Azhar Ali Khan, Allah Ditta Abid, Muhammad Sohail Shahzad
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by Jia Liu, Shu-Jie Sun, Ye Lu, Xin Ping, Wan Zhang, Lin Pei
ObjectiveThis study aims to investigate the relationship between taste dysfunction and depression among patients with schizophrenia, to achieve early detection of depression in clinical practice.
MethodsFollowing PRISMA guidance, a comprehensive literature search was conducted globally, covering papers published from 1961 to June 2023. A total of 17 manuscripts were selected through meta-analysis and sensitivity analysis... Читать дальше...
by The PLOS ONE Staff
by Medet Aktayev, Sergey Subbotin, Assan Aidarkhanov, Almira Aidarkhanova, Lyubov Timonova, Natalya Larionova
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by Hikaru Ishida, Norihisa Yasui, Atsuko Yamashita
Taste receptor type 1 (T1r) proteins are responsible for recognizing nutrient chemicals in foods. In humans, T1r2/T1r3 and T1r1/T1r3 heterodimers serve as the sweet and umami receptors that recognize sugars or amino acids and nucleotides, respectively. T1rs are conserved among vertebrates, and T1r2a/T1r3 from medaka fish is currently the only member for which the structure of the ligand-binding domain (LBD) has been solved. T1r2a/T1r3 is... Читать дальше...
by Qiaona Xing, Huey Pyng Tan, Su Wan Gan
As the industrial structure changes, the severe shortage of high-quality technical and skilled talent in China is one of the most significant factors affecting the high-quality development of China’s economy. Bridging the gap between cultivating talent from new undergraduate vocational universities and the demand for industrial talent is regarded as an efficient strategy to address the talent shortage. In addressing the gap, China is hindered by a... Читать дальше...
by Surya Paudel, Ilias Apostolakos, Ronald Vougat Ngom, Giuditta Tilli, Helena C. de Carvalho Ferreira, Alessandra Piccirillo
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by Sharifa Ezat Wan Puteh, Mohd Shafiq Aazmi, Muhammad Nazri Aziz, Noor ‘Adilah Kamarudin, Jamal I-Ching Sam, Ravindran Thayan, Wan Rozita Wan Mahiyuddin, Wan Noraini Wan Mohamed Noor, Adelina Cheong, Clotilde El Guerche-Séblain, Jean Khor, Eva Nabiha Zamri, Jia-Yong Lam, Zamberi Sekawi
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by Chunli Dong, Liyan Zhao, Xiongtao Liu, Ling Dang, Xin Zhang
BackgroundThe development of endometrial cancer (EC) is closely related to the abnormal activation of the estrogen signaling pathway. Effective diagnostic markers are important for the early detection and treatment of EC.
MethodWe downloaded single-cell RNA sequencing (scRNA-seq) and spatial transcriptome (ST) data of EC from public databases. Enrichment scores were calculated for EC cell subpopulations using the “AddModuleScore” function and the AUCell package... Читать дальше...
by Qihong Dai, Cory D. Suski
Heatwaves are becoming more frequent and intensified with climate change. Freshwater ecosystems are among the most threatened, within which, differing responses between cool- and warmwater species to heatwaves can lead to fundamental changes in communities. Physiological experiments can identify potential mechanisms underlying the impacts of such heatwaves on fish communities. In the current study, we quantified the oxygen consumption rate, aerobic scope and swimming... Читать дальше...
by Paulina Guzmán-Guzmán, Eduardo Valencia-Cantero, Gustavo Santoyo
Trichoderma uses different molecules to establish communication during its interactions with other organisms, such as effector proteins. Effectors modulate plant physiology to colonize plant roots or improve Trichoderma’s mycoparasitic capacity. In the soil, these fungi can establish relationships with plant growth–promoting bacteria (PGPBs), thus affecting their overall benefits on the plant or its fungal prey, and possibly, the role of effector proteins. Читать дальше...
by Leire Ambrosio, Jacqui Morris, Danielle Lambrick, James Faulkner, Eric Compton, Mari Carmen Portillo
by Yannik Roell, Laura Pezzi, Anyela Lozano-Parra, Daniel Olson, Jane Messina, Talia Quandelacy, Jan Felix Drexler, Oliver Brady, Morteza Karimzadeh, Thomas Jaenisch
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by Sophie Welsche, Pierre H. H. Schneeberger, Jan Hattendorf, Somphou Sayasone, Eveline Hürlimann, Jennifer Keiser
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by Taylor Hinnant, Wenxiu Ning, Terry Lechler
Tissues are subject to multiple mechanical inputs at the cellular level that influence their overall shape and function. In the small intestine, actomyosin contractility can be induced by many physiological and pathological inputs. However, we have little understanding of how contractility impacts the intestinal epithelium on a cellular and tissue level. In this study, we probed the cell and tissue-level effects of contractility by using mouse... Читать дальше...
by Elika Garg, Paola Arguello-Pascualli, Olga Vishnyakova, Anat R. Halevy, Samantha Yoo, Jennifer D. Brooks, Shelley B. Bull, France Gagnon, Celia M. T. Greenwood, Rayjean J. Hung, Jerald F. Lawless, Jordan Lerner-Ellis, Jessica K. Dennis, Rohan J. S. Abraham, Jean-Michel Garant, Bhooma Thiruvahindrapuram, Steven J. M. Jones, CGEn HostSeq Initiative , Lisa J. Strug, Andrew D. Paterson, Lei Sun, Lloyd T. Elliott
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by Kelli D. Fenelon, Julia Krause, Theodora Koromila
Only a few short decades have passed since the sequencing of GFP, yet the modern repertoire of transgenically encoded optical tools implies an exponential proliferation of ever improving constructions to interrogate the subcellular environment. A myriad of tags for labeling proteins, RNA, or DNA have arisen in the last few decades, facilitating unprecedented visualization of subcellular components and processes. Development of a broad array... Читать дальше...
by Chris M. Ward, Cristobal A. Onetto, Steven Van Den Heuvel, Kathleen M. Cuijvers, Laura J. Hale, Anthony R. Borneman
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by Matteo Martin, Morten Gram Pedersen
Cyclic AMP controls neuronal ion channel activity. For example hyperpolarization-activated cyclic nucleotide–gated (HCN) and M-type K+ channels are activated by cAMP. These effects have been suggested to be involved in astrocyte control of neuronal activity, for example, by controlling the action potential firing frequency. In cortical neurons, cAMP can induce mixed-mode oscillations (MMOs) consisting of small-amplitude, subthreshold oscillations separating complete action potentials... Читать дальше...
by Rachael Pung, Timothy W. Russell, Adam J. Kucharski
The epidemiological characteristics of SARS-CoV-2 transmission have changed over the pandemic due to emergence of new variants. A decrease in the generation or serial intervals would imply a shortened transmission timescale and, hence, outbreak response measures would need to expand at a faster rate. However, there are challenges in measuring these intervals. Alongside epidemiological changes, factors like varying delays in outbreak response... Читать дальше...