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Новости за 10.05.2024

Case-area targeted interventions during a large-scale cholera epidemic: A prospective cohort study in Northeast Nigeria

Plos.org 

by Jennifer OKeeffe, Lindsay Salem-Bango, Michael R. Desjardins, Daniele Lantagne, Chiara Altare, Gurpreet Kaur, Thomas Heath, Kanaganathan Rangaiya, Patricia Oke-Oghene Obroh, Ahmadu Audu, Baptiste Lecuyot, Timothée Zoungrana, Emmanuel Emeka Ihemezue, Solomon Aye, Mustafa Sikder, Shannon Doocy, Qiulin Wang, Melody Xiao, Paul B. Spiegel

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A novel method for multiple phenotype association studies based on genotype and phenotype network

Plos.org 

by Xuewei Cao, Shuanglin Zhang, Qiuying Sha

Joint analysis of multiple correlated phenotypes for genome-wide association studies (GWAS) can identify and interpret pleiotropic loci which are essential to understand pleiotropy in diseases and complex traits. Meanwhile, constructing a network based on associations between phenotypes and genotypes provides a new insight to analyze multiple phenotypes, which can explore whether phenotypes and genotypes might be related to each other at a higher level of cellular and organismal organization. Читать дальше...

Machine learning and multi-omics data reveal driver gene-based molecular subtypes in hepatocellular carcinoma for precision treatment

Plos.org 

by Meng Wang, Xinyue Yan, Yanan Dong, Xiaoqin Li, Bin Gao

The heterogeneity of Hepatocellular Carcinoma (HCC) poses a barrier to effective treatment. Stratifying highly heterogeneous HCC into molecular subtypes with similar features is crucial for personalized anti-tumor therapies. Although driver genes play pivotal roles in cancer progression, their potential in HCC subtyping has been largely overlooked. This study aims to utilize driver genes to construct HCC subtype models and unravel their molecular mechanisms. Читать дальше...

Plant viruses traveling without passport

Plos.org 

by Cristina Sáez, Israel Pagán

All plant viruses were thought to encode in its genome a movement protein that acts as a “passport,” allowing active movement within the host. A new study in PLOS Biology characterizes the first plant virus that can colonize its host without encoding this protein. All plant viruses were thought to encode in its genome a movement protein that acts as a “passport”, allowing active movement within the host. This primer highlights a study that characterizes the... Читать дальше...

Elephant Rumblings: Miller seen as top ROY contender

Athletics Nation 

Neville E. Guard-USA TODAY Sports

MLB news roundup

Happy Friday, Athletics Nation!

Had enough of Mason Miller yet? Yeah, me either.

Jim Bowden at The Athletic ranks Miller as the top rookie in the American League. Meanwhile, Ken Rosenthal at The Athletic cited an anonymous source within the A’s organization that potential suitors are already calling about Miller, but no offer has yet been made that comes close to the A’s asking price. JToster has more details and analysis right here on AN. Читать дальше...



Jhonkensy Noel’s extra inning home run salvages a rough day for the afilliates

Let's Go Tribe 

Cleveland Guardians minor league recap for Thursday, May 10, 2024

Columbus Clippers 6, Iowa Cubs 4

Box Score · Clippers improve to 15-20

The Columbus Clippers were the only Cleveland Guardians affiliate to win today. Juan Brito went 3-5, which is good to see. I’m hoping he can get it going here soon. Daniel Schneeman went 1-5 with a 2 RBI single in the top of the 8th. Johnathan Rodriguez stays hot with a 2-4 performance with one walk. He’s up to hitting .291 with an .872 OPS. Читать дальше...

The Football News Show

BBC Sport (Football) 

It is still all to play for on the penultimate weekend of the Premier League.

Logistics, NEVs in focus for next phase of automotive industry growth

Engineeringnews.co.za 

Efficient logistics to move vehicles and automotive components up and down the value chain and adapting the local industry to new energy vehicles (NEVs) is crucial to shape the trajectory of the industry into the future, industry development agency Automotive Industry Development Centre (AIDC) chairperson Meloney van Eck said this week. Speaking at a Gauteng government- and AIDC-hosted automotive industry roundtable discussion, in Midrand, on May 9, she said it was important for industry leaders... Читать дальше...

You Can’t Cross The Same River Twice

Jalopnik.com 

The Kia EV6, in many ways, competes with every other midsize crossover out there. There’s just this one odd difference — electric power — that separates it from the CR-Vs and Rav4s with which it shares its size, seating, and purpose. That one change, though, makes all the difference in the world.

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