UFC Fight Night 220 predictions: Nikita Krylov or Ryan Spann in Las Vegas showdown?

The UFC is back in its home base in Las Vegas this week with a pair of light heavyweights at the top of the card.

UFC Fight Night 220 takes place Saturday at the UFC Apex in Las Vegas. The card streams on ESPN+.

(Click here to open a PDF of the staff picks grid in a separate window.)

In the main event, Nikita Krylov (29-9 MMA, 10-7 UFC) takes on Ryan Spann (21-7 MMA, 7-2 UFC) at 205 pounds. Krylov is slight favorite at -170 at Tipico Sportsbook; the comeback on Spann is +145. But our 11 editors, writers, radio hosts and videographers have flipped the script and are are siding with underdog Spann at a hefty 9-2 clip.

In the co-feature, Brendan Allen (20-5 MMA, 8-2 UFC) meets Andre Muniz (23-4 MMA, 5-0 UFC) at middleweight. Muniz is a -240 favorite, and he’s got a near-unanimous picks lead at 10-1.

Also on the main card, Don'Tale Mayes (9-4 MMA, 2-2 UFC) fights Augusto Sakai (15-5-1 MMA, 4-4 UFC) in a heavyweight bout that is the most contentious among our staff members, and it’s still a relative blowout. Sakai is just a slight favorite at -130, but he has a big 8-3 lead from our pickers.

Our lone unanimous pick on the main card is Tatiana Suarez (8-0 MMA, 5-0 UFC), who is a massive 8-1 favorite over Montana De La Rosa (12-7-1 MMA, 5-3-1 UFC) in their women’s flyweight fight.

And to open the main card, Yohan Lainesse (9-1 MMA, 1-1 UFC) takes on Mike Malott (8-1-1 MMA, 1-0 UFC) in a welterweight fight between a pair of Canadians. Malott is more than a 2-1 favorite, and he has a big 9-2 edge in the picks.

In the MMA Junkie consensus picks, Spann (57 percent), Muniz (68 percent), Sakai (56 percent), Suarez (88 percent) and Malott (78 percent) are the choices.

Check out all the picks above.

For more on the card, visit MMA Junkie’s event hub for UFC Fight Night 220.