Jane Fonda says she felt 'totally paranoid' after taking the psychedelic peyote with Lily Tomlin

• Jane Fonda talked about taking peyote with Lily Tomlin on "The Late Show With Stephen Colbert" Thursday.
• Fonda said the experience was "horrible" and that it made her feel "totally paranoid."
• Peyote, a small cactus, is often ingested for its psychedelic effects that can mimic those of LSD.

Jane Fonda says that taking peyote with costar Lily Tomlin was a terrible experience.

The pair appeared on Thursday's episode of "The Late Show With Stephen Colbert" and recalled the time they took the psychedelic together. 

"I've always had really good experiences with peyote, but the time we took it together, it was horrible," Fonda told Colbert. "I [was] totally paranoid."

"Oh yeah, it was the worst. I love it, but I wouldn't do peyote unless you were with a guide," Fonda said.

"Like a shaman," Tomlin added. "As I am."

Colbert then asked whether or not he should try peyote to which Fonda replied: "I think you need a little peyote, yeah. And I'll be your guide."

According to the DEA, peyote is a "small, spineless cactus" that contains mescaline, a hallucinogen. When taken, its effects can be similar to those of PCP, mushrooms, and LSD. 

Peyote is commonly ingested by boiling peyote buttons, small discs found on the top of the cactus, in water, and drinking the liquid. The plant, found in the Southwest and Mexico, is often used by indigenous people of these regions as part of "their religious rites," per the DEA.

This isn't Fonda's first time speaking publicly about her experiences with peyote.

In a 2015 interview with GQ, Fonda said: "It's not my drug of choice; I've never had any profound visions, but many of my friends have. You see incredible shapes and colors and patterns, and sometimes you have cosmic breakthroughs. I haven't."

Fonda and Tomlin appeared on the show to promote their new film "Moving On."  

In the film, Fonda and Tomlin play two estranged friends who reunite to kill the husband of their recently deceased friend.

This film is just the latest in the string of projects they have starred in together. Previously the duo appeared together in "9 to 5," the Netflix series "Grace and Frankie," and most recently, "80 for Brady."

"Moving On" hits theaters on March 17.