March Madness Picks for Sweet 16: Two Bets and Predictions for Friday's Games

Both remaining No. 1 seeds in the men's NCAA tournament are in action on Friday, so look out for big spreads on the second day of the Sweet 16.

The last two remaining No. 1 seeds in the men's NCAA tournament are both scheduled to play on the second day of the Sweet 16.

The first game to tip off pits the top overall seed, Alabama, against No. 5 San Diego State. And the next game will feature No. 1 Houston and No. 5 Miami, two teams that are both fresh off deep March Madness runs and are looking to repeat that recent success.

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