76Bio is seeking a highly motivated and talented Medicinal Chemists to help build a delivery platform to realize the potential of our TPD platform. The individual will be responsible for the design of novel lipids and delivery materials to enable improved mRNA delivery to specific targets. The individual will work closely with the Formulation Science team to develop and drive the design of novel lipid-based delivery vehicles. They will be accountable for the design of screening cascades (in vitro and in vivo) and developing the structure activity relationships of different classes of lipid nanoparticles. They will be an integral member of a cross functional team, providing interpretation of data and contributing to the strategic direction of the project.
Key Responsibilities:
Develop the medicinal chemistry strategy and work in collaboration with the formulation scientists to execute on a formulation strategy for testing new lipid components
Design and develop novel lipid components and LNP compositions to improve LNP delivery to tumor
Manage external chemistry resources for the synthesis of new targets
Ensure efficiency of workflows and integration of high-throughput methods where feasible
Collaborate with biology colleagues on designing assays to better understand LNP biology
Open to all degree levels; you probably need a fair bit of industry experience. Best wishes to those interested.
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