DNA-repair protein complex is a shapeshifter, reconfiguring itself to meet the demands of each task

Transcription factor IIH, or TFIIH, pronounced "TF two H," is a veritable workhorse among the protein complexes that control human cell activity. It plays critical roles both in transcription—the highly regulated enzymatic synthesis of RNA from a DNA template—and in the repair of damaged DNA. But how can one protein assembly participate in two such vastly different and extremely important genomic tasks?