Steric zipper interactions in artificial crystalline peptide β-sheets

Steric zippers are a specific type of hydrophobic packing structure that form between two adjacent layers of peptide β-sheets in amyloid and similar fibrils. These structures play a crucial role in the stability and propagation of amyloid fibrils, and can aid in designing new peptide-based materials. However, creating artificial steric zippers is challenging owing to the strong aggregation tendency of β-sheet peptides. This often leads to the formation of gels and fibrils, making it difficult to obtain structures in their crystalline form.