Wounding the stroma: Docetaxel’s role in dormant breast cancer escape

by Tyler T. Cooper, Lynne-Marie Postovit

The mechanistic underpinnings of breast cancer recurrence following periods of dormancy are largely undetermined. A new study in PLOS Biology reveals that docetaxel-induced injury of tumour stromal cells stimulates the release of cytokines that support dormancy escape of breast cancer cells. The mechanistic underpinnings of breast cancer recurrence following periods of dormancy are largely undetermined. This Primer explores a new study in PLOS Biology which reveals that docetaxel-induced injury of tumor stromal cells stimulates the release of cytokines that support dormancy escape of breast cancer cells.