In November 2023, BioDesign Research published a perspective article titled "Ice Cores as a Source for Antimicrobials: From Bioprospecting to Biodesign," outlining a revolutionary approach to antibiotic discovery using ice cores. This innovative article comes at a pivotal time, as the golden age of antibiotic discovery has passed and the threat of antimicrobial resistance (AMR) is looming, projected to cause 10 million deaths per year by 2050.