Genetic code robustness and protein evolvability are correlated and protein-specific

by Brian P. H. Metzger

The relationship between genetic code robustness and protein evolvability is unknown. A new study in PLOS Biology using in silico rewiring of genetic codes and functional protein data identified a positive correlation between code robustness and protein evolvability that is protein-specific. The relationship between genetic code robustness and protein evolvability is unknown. This Primer explores a new PLOS Biology study which uses in silico rewiring of genetic codes and functional protein data to identify a positive correlation between code robustness and protein evolvability that is protein-specific.