Colorectal carcinoma – Duke Staging and Management

0 - Tis, N0, M0

Limited to mucosa

>95%

Local excision/polypectomy → Surveillance

No

No

II - T3-4, N0, M0

B

B reached bowel wall (muscularis propria)

70%

Wide surgical resection + Anastomosis

Adjuvant if: lymph node sampling <12, poorly differentiated, local invasion, occlusion/perforation, pT4)
FOLFOX or CapeOX

Yes, for rectal cancer (give with 5-FU as sensitizer)

IV - any T, any N, M1

D

D istant metastasis

10%

Surgical resection for - obstruction, some patients with hepatic, lung and peritoneal metastases