Can the tumor neural niche be targeted to re-program cancer?

by Erica K. Sloan, Joo Sang Lee

Interactions between the peripheral nervous system and solid tumors influence cancer progression and treatment response. Defining the 3D tumor neural niche using spatial omics and AI technologies will identify new opportunities for targeted therapies to stop cancer progression. Interactions between the peripheral nervous system and solid tumors influence cancer progression and treatment response. This Perspective argues that defining the 3D tumor neural niche using spatial omics and AI technologies could identify new opportunities for targeted therapies to stop cancer progression.