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2022

Новости за 25.07.2022

Human papillomaviruses sensitize cells to DNA damage induced apoptosis by targeting the innate immune sensor cGAS

Plos.org 

by Elona Gusho, Laimonis A. Laimins

The cyclic GMP-AMP synthase (cGAS) is a critical regulator of the innate immune response acting as a sensor of double-strand DNAs from pathogens or damaged host DNA. Upon activation, cGAS signals through the STING/TBK1/IRF3 pathway to induce interferon expression. Double stranded DNA viruses target the cGAS pathway to facilitate infection. In HPV positive cells that stably maintain viral episomes, the levels of cGAS were found to be significantly increased... Читать дальше...

The role of information in consumer preferences for sustainable certified palm oil products in Germany

Plos.org 

by Christoph Richartz, Awudu Abdulai

Food products are often subject to information asymmetries, which are commonly supposed to be reduced by labels and certifications. However, as the number of labels increases, consumers tend to get confused, bored or impatient and stop using them to make product choices. This study uses data from a discrete choice experiment, conducted in Germany, to analyze consumers’ preferences and willingness-to-pay (WTP) for sustainability indicators on products that contain palm oil as an ingredient. Читать дальше...



Urogenital schistosomiasis prevalence and diagnostic performance of urine filtration and urinalysis reagent strip in schoolchildren, Ethiopia

Plos.org 

by Ketema Deribew, Delenasaw Yewhalaw, Berhanu Erko, Zeleke Mekonnen

Background

Urogenital schistosomiasis has been known to be endemic in several lowland areas of Ethiopia. It is caused by Schistosoma haematobium and causes considerable public health problems to schoolchildren. Ethiopia, after mapping the distribution of the disease (2013 to 2015), launched school-based mass deworming program to treat schoolchildren for schistosomiasis and soil-transmitted helminthiasis (STH) across the country since 2015. Читать дальше...

Astragalus polysaccharides and astragaloside IV alleviate inflammation in bovine mammary epithelial cells by regulating Wnt/β-catenin signaling pathway

Plos.org 

by Jiaqi Fan, Fang Jia, Yang Liu, Xuezhang Zhou

The Wnt/β-catenin signaling regulates cell renewal and repair and is closely associated with inflammation. Astragalus polysaccharides (APS) and astragaloside IV (AS-IV), which are the main active substances extracted from Radix Astragali, protect cells by regulating Wnt signaling in cells, exerting antiinflammatory, antioxidant, and antistress effects. However, the mechanisms by which APS and AS-IV interact with Wnt signaling to achieve their... Читать дальше...

Glycemic variability and all-cause mortality in a large prospective southern European cohort of patients with differences in glycemic status

Plos.org 

by Miguel A. Salinero-Fort, F. Javier San Andrés-Rebollo, Juan Cárdenas-Valladolid, José M. Mostaza, Carlos Lahoz, Fernando Rodriguez-Artalejo, Paloma Gómez-Campelo, Pilar Vich-Pérez, Rodrigo Jiménez-García, Ana López de Andrés, José M. de Miguel-Yanes, on behalf the MADIABETES and SPREDIA Consortium

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Scientific collaboration, research funding, and novelty in scientific knowledge

Plos.org 

by Hyunha Shin, Keungoui Kim, Dieter F. Kogler

Disruptive advancements in science and technology often rely on new ideas and findings, which in turn brings us to focus on the value of novelty in scholarly activities. Using Web of Science publication data from European regions for the period between 2008 and 2017, this study examines, first, the impact of scientific collaboration on novelty of research. Here, five levels of collaboration are considered for each article–country, three levels of regions... Читать дальше...

Profit distribution mechanism of agricultural supply chain based on fair entropy

Plos.org 

by Fuzhen Gu, Xun Yu

This paper constructs a profit distribution model under centralized decision-making by taking the secondary agricultural supply chain as an example. Moreover, it introduces resources and risk as two factors to form significant weights and then designs a fair profit distribution mechanism of the supply chain according to the weights. Finally, this paper solves the optimal solution of the profit distribution coefficient by using fair entropy. Research results find that... Читать дальше...

Depression and anxiety and their associated factors among caregivers of children and adolescents with epilepsy in three selected hospitals in Amhara region, Ethiopia: A cross-sectional study

Plos.org 

by Mekonnen Tsehay, Mogesie Necho, Asmare Belete, Mengesha Srahbzu

Background

The prevalence rates of depression and anxiety are unforeseen among primary caregivers of patients with epilepsy. Little attention is being given to the problem in Ethiopia.

Objectives

This study aimed to assess the prevalence and associated factors of depression and anxiety among caregivers of children and adolescents with epilepsy in three selected hospitals in Amhara region, Ethiopia.

Methods

Institution-based... Читать дальше...

An electronic transition-based bare bones particle swarm optimization algorithm for high dimensional optimization problems

Plos.org 

by Hao Tian, Jia Guo, Haiyang Xiao, Ke Yan, Yuji Sato

An electronic transition-based bare bones particle swarm optimization (ETBBPSO) algorithm is proposed in this paper. The ETBBPSO is designed to present high precision results for high dimensional single-objective optimization problems. Particles in the ETBBPSO are divided into different orbits. A transition operator is proposed to enhance the global search ability of ETBBPSO. The transition behavior of particles gives the swarm more chance to escape from local minimums. Читать дальше...





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