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Новости за 23.03.2023

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New workflow predicts drug targets against SARS-CoV-2 via metabolic changes in infected cells

Plos.org 
En

by Nantia Leonidou, Alina Renz, Reihaneh Mostolizadeh, Andreas Dräger

COVID-19 is one of the deadliest respiratory diseases, and its emergence caught the pharmaceutical industry off guard. While vaccines have been rapidly developed, treatment options for infected people remain scarce, and COVID-19 poses a substantial global threat. This study presents a novel workflow to predict robust druggable targets against emerging RNA viruses using metabolic networks and information of the viral structure and its genome sequence. Читать дальше...

Theta-gamma phase amplitude coupling in a hippocampal CA1 microcircuit

Plos.org 
En

by Adam Ponzi, Salvador Dura-Bernal, Michele Migliore

Phase amplitude coupling (PAC) between slow and fast oscillations is found throughout the brain and plays important functional roles. Its neural origin remains unclear. Experimental findings are often puzzling and sometimes contradictory. Most computational models rely on pairs of pacemaker neurons or neural populations tuned at different frequencies to produce PAC. Here, using a data-driven model of a hippocampal microcircuit, we demonstrate... Читать дальше...

Mitochondrial network structure controls cell-to-cell mtDNA variability generated by cell divisions

Plos.org 
En

by Robert C. Glastad, Iain G. Johnston

Mitochondria are highly dynamic organelles, containing vital populations of mitochondrial DNA (mtDNA) distributed throughout the cell. Mitochondria form diverse physical structures in different cells, from cell-wide reticulated networks to fragmented individual organelles. These physical structures are known to influence the genetic makeup of mtDNA populations between cell divisions, but their influence on the inheritance of mtDNA at divisions remains less understood. Читать дальше...

Авторские публикации Smi24.net

Ten simple rules for socially responsible science

Plos.org 
En

by Alon Zivony, Rasha Kardosh, Liadh Timmins, Niv Reggev

Guidelines concerning the potentially harmful effects of scientific studies have historically focused on ethical considerations for minimizing risk for participants. However, studies can also indirectly inflict harm on individuals and social groups through how they are designed, reported, and disseminated. As evidenced by recent criticisms and retractions of high-profile studies dealing with a wide variety of social issues, there is... Читать дальше...

Primate protein-ligand interfaces exhibit significant conservation and unveil human-specific evolutionary drivers

Plos.org 
En

by Sean B. King, Mona Singh

Despite the vast phenotypic differences observed across primates, their protein products are largely similar to each other at the sequence level. We hypothesized that, since proteins accomplish all their functions via interactions with other molecules, alterations in the sites that participate in these interactions may be of critical importance. To uncover the extent to which these sites evolve across primates, we built a structurally-derived dataset of ~4,200... Читать дальше...



Elephant Rumblings: Rotation picture still unsettled

Athletics Nation 
En

Rick Scuteri-USA TODAY Sports

MLB news roundup

Happy Thursday, AN!

The rotation picture is changing on what seems like a daily basis. With the recent news that Drew Rucinski is dealing with an injury and is questionable for Opening Day, that opens up yet another spot in the rotation for one of the young guns.

With Shintaro Fujinami guaranteed a spot and James Kaprielian looking likely for the rotation, there would be three open slots available in Rucinski does indeed need a stint on the injured list. Читать дальше...

The Royals Review Opening Day roster projection

Royals Review 
En

Photo by Jamie Squire/Getty Images

One week to go!

A week from today the Royals begin the regular season at home against the Minnesota Twins. The team is largely the same from last year’s squad, with a few minor off-season moves. The have pinned their hopes on a youth movement with a lineup that could have as many as 7 or 8 hitters age 26 or younger, and a pitching rotation that features young arms like Brady Singer and Daniel Lynch.

While most of the core returns, there... Читать дальше...

[Softball] Bears Take Down Harriers

Shawnee State Bears 
En

The Shawnee State Softball team traveled to Hamilton, Ohio to take on Miami University-Hamilton, in a Wednesday double header. The Bears took both games, scoring their opponent by 27 runs. 

Hubble monitors changing weather and seasons on Jupiter and Uranus

Esa.int 
En

Ever since its launch in 1990, the NASA/ESA Hubble Space Telescope has been an interplanetary weather observer, keeping an eye on the ever-changing atmospheres of the largely gaseous outer planets. And it’s an unblinking eye that allows Hubble’s sharpness and sensitivity to monitor a kaleidoscope of complex activities over time. Today new images are shared of Jupiter and Uranus.

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Электрокоагуляция по науке: Алексей Горшков о роли гидроксида алюминия в очистке воды Компания «Гранд Сервис Экспресс» на фоне задержки рейсов в столичных аэропортах включила дополнительные купейные вагоны в оба состава поезда №53/54 «Гранд Экспресс» сообщением Санкт-Петербург – Москва и Москва –... Аналитика МТС Банка и Ozon fresh: россияне все чаще предпочитают занятия спортом, активный отдых и протеиновую продукцию Коммунальный долг: Мосгорсуд вновь взыскал с Тимати задолженность по ЖКХ

Outlander Season 7: Starz Drops First Look Images & the Date Our Summer on Fraser's Ridge Begins!

Блог сайта «Face Tube is a fun name,» 
En

The Droughtlander is almost over!

Starz revealed the very date that our Summer on Fraser's Ridge will begin.

We've got your first look photos and even more news about what's ahead.

Starz announced today the June 16 return of its fan-favorite time-traveling drama series Outlander, confirming the upcoming seventh season will be split into two parts of eight episodes each, with the back half airing in 2024.

It was previously announced that the seventh season would be an extended 16 episodes. Читать дальше...

Mark Cuban left bemused as the Golden State Warriors score bizarre basket in 127-125 road win over the Dallas Mavericks - CNN

Sports - Google News (us) 
En

  1. Mark Cuban left bemused as the Golden State Warriors score bizarre basket in 127-125 road win over the Dallas Mavericks  CNN
  2. Mark Cuban to file protest of Mavericks loss to Warriors  ESPN
  3. WARRIORS at MAVERICKS | FULL GAME HIGHLIGHTS | March 22, 2023  NBA
  4. Mavericks to file protest after alleged ref miscommunication leads to world's easiest basket for Warriors  Yahoo Sports
  5. Stephen A. on Mavs' loss: Their inability to stop Steph Curry is the reason they lost! Читать дальше...

Спонсорский контент
Russia24.pro
Искусство как память: в Театре Российской Армии прошел уникальный балетный марафон Нужно ли праздновать патриотические праздники в колониях-поселениях? Глобальное масштабирование: компания «Газинформсервис» участвует в обсуждении применения электронной транспортной накладной с ЕЭК ООН Киберпреступность эволюционировала, защита не может строиться только на поиске вредоносного кода
Ria.city
Нужно ли праздновать патриотические праздники в колониях-поселениях? Глобальное масштабирование: компания «Газинформсервис» участвует в обсуждении применения электронной транспортной накладной с ЕЭК ООН Финальный аккорд проекта «Классика для всей семьи» в Хакасии: искусство объединяет и вдохновляет Искусство как память: в Театре Российской Армии прошел уникальный балетный марафон


Ru24.net
Губернатора будем выбирать три дня в сентябре. Кто еще (кроме Паслера) метит в кресло? Уральский клондайк. 1. Западные предприниматели оказались проворнее русских Ответственность, взаимная поддержка, общность интересов – одни из ключевых элементов семейных отношений Барнаул оказался в хвосте рейтинга российских городов по отраслевым зарплатам

Все города России
Smi24.net
В Минэнерго составили реестр оборудования для майнинга Финальный аккорд проекта «Классика для всей семьи» в Хакасии: искусство объединяет и вдохновляет Москва побила летний температурный рекорд ИТ-компания TYMY запустила сервис Public API для взаимодействия финтеха и банков-партнеров платформы

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