by Catherine M. Bjerum, Benjamin G. Koudou, Allassane F. Ouattara, Daphne Lew, Charles W. Goss, Pascal T. Gabo, Christopher L. King, Peter U. Fischer, Gary J. Weil, Philip J. Budge
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by Isato Yoshioka, Yugo Mori, Ahmed Hassan Fahal, Emmanuel Edwar Siddig, Satoshi Kaneko, Takashi Yaguchi
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by Xiujiao Xia, Huilin Zhi, Zehu Liu
BackgroundCutaneous disseminated sporotrichosis (CDS), also called hematogenous sporotrichosis, is a rare condition that usually affects immunocompromised patients. The current work presents the case of a woman with diabetes mellitus associated with CDS.
Case presentationA 59-year-old woman with diabetes mellitus presented with a two-year history of ulcerated rashes on the left ankle and both sides of the jaw. Physical examination revealed three... Читать дальше...
by Yu-ting Ren, Hong-pan Tian, Jia-le Xu, Man-qing Liu, Kun Cai, Shu-liang Chen, Xue-bing Ni, Yi-rong Li, Wei Hou, Liang-jun Chen
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by Lindsey Smith Taillie, Maxime Bercholz, Carmen E. Prestemon, Isabella C. A. Higgins, Anna H. Grummon, Marissa G. Hall, Lindsay M. Jaacks
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by Amanda Forde, Gibran Hemani, John Ferguson
Genome-wide association studies (GWAS) are commonly used to identify genomic variants that are associated with complex traits, and estimate the magnitude of this association for each variant. However, it has been widely observed that the association estimates of variants tend to be lower in a replication study than in the study that discovered those associations. A phenomenon known as Winner’s Curse is responsible for this upward bias present... Читать дальше...
by Nurlan Kerimov, Ralf Tambets, James D. Hayhurst, Ida Rahu, Peep Kolberg, Uku Raudvere, Ivan Kuzmin, Anshika Chowdhary, Andreas Vija, Hans J. Teras, Masahiro Kanai, Jacob Ulirsch, Mina Ryten, John Hardy, Sebastian Guelfi, Daniah Trabzuni, Sarah Kim-Hellmuth, William Rayner, Hilary Finucane, Hedi Peterson, Abayomi Mosaku, Helen Parkinson, Kaur Alasoo
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by Hannah J. Smith, Anne Lanjuin, Arpit Sharma, Aditi Prabhakar, Ewelina Nowak, Peter G. Stine, Rohan Sehgal, Klement Stojanovski, Benjamin D. Towbin, William B. Mair
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by Susanna K. Birnbaum, Jennifer D. Cohen, Alexandra Belfi, John I. Murray, Jennifer R. G. Adams, Andrew D. Chisholm, Meera V. Sundaram
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by Calum A. Graham, Pirita Paajanen, Keith J. Edwards, Antony N. Dodd
Circadian rhythms coordinate the responses of organisms to their daily fluctuating environments, by establishing a temporal program of gene expression. This schedules aspects of metabolism, physiology, development and behaviour according to the time of day. Circadian regulation in plants is extremely pervasive, and is important because it underpins both productivity and seasonal reproduction. Circadian regulation extends... Читать дальше...
by Claire Ecotière, Sylvain Billiard, Jean-Baptiste André, Pierre Collet, Régis Ferrière, Sylvie Méléard
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by Christopher E. Overton, Sam Abbott, Rachel Christie, Fergus Cumming, Julie Day, Owen Jones, Rob Paton, Charlie Turner, Thomas Ward
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by Bayarbaatar Amgalan, Chi-Ping Day, Teresa M. Przytycka
There is a growing awareness that tumor-adjacent normal tissues used as control samples in cancer studies do not represent fully healthy tissues. Instead, they are intermediates between healthy tissues and tumors. The factors that contribute to the deviation of such control samples from healthy state include exposure to the tumor-promoting factors, tumor-related immune response, and other aspects of tumor microenvironment. Characterizing... Читать дальше...
by Serena Aneli, Piero Fariselli, Elena Chierto, Carla Bini, Carlo Robino, Giovanni Birolo
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by Seirana Hashemi, Zahra Razaghi-Moghadam, Zoran Nikoloski
Intracellular fluxes represent a joint outcome of cellular transcription and translation and reflect the availability and usage of nutrients from the environment. While approaches from the constraint-based metabolic framework can accurately predict cellular phenotypes, such as growth and exchange rates with the environment, accurate prediction of intracellular fluxes remains a pressing problem. Parsimonious flux balance analysis... Читать дальше...
by Zengmiao Wang, Peiyi Wu, Lin Wang, Bingying Li, Yonghong Liu, Yuxi Ge, Ruixue Wang, Ligui Wang, Hua Tan, Chieh-Hsi Wu, Marko Laine, Henrik Salje, Hongbin Song
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by Bo Wang, Yifeng Zhang
Motion is an important aspect of visual information. The directions of visual motion are encoded in the retina by direction-selective ganglion cells (DSGCs). ON-OFF DSGCs and ON DSGCs co-stratify with starburst amacrine cells (SACs) in the inner plexiform layer and depend on SACs for their direction selectivity. J-type retinal ganglion cells (J-RGCs), a type of OFF DSGCs in the mouse retina, on the other hand, do not co-stratify with SACs, and how direction selectivity in J-RGCs emerges has not been understood. Читать дальше...
by Chen Liu, Andriani Mentzelopoulou, Fotini Papagavriil, Prashanth Ramachandran, Artemis Perraki, Lucas Claus, Sebastian Barg, Peter Dörmann, Yvon Jaillais, Philipp Johnen, Eugenia Russinova, Electra Gizeli, Gabriel Schaaf, Panagiotis Nikolaou Moschou
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by Xenia Chelius, Veronika Bartosch, Nathalie Rausch, Magdalena Haubner, Jana Schramm, Ralf J. Braun, Till Klecker, Benedikt Westermann
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By Erik Barnes Published: September 18th, 2023
After witnessing native oyster reefs dwindle for over two decades, a team of researchers and conservationists from the University of New Hampshire College of Life Sciences and Agriculture are working hard to reverse these trends.
Settle in for some bonding time. These are our favorite cooperative titles for two to eight players, all playable on a single TV.
PayPal's new stablecoin offering should be setting off alarms at traditional banks, because it could seriously challenge their dominance in the payments space.
@ Anchorage, AK
May 2023
I always welcome the opportunity to photograph the colorful aircraft of Rust’s Flying Service moored at Lake Hood. Lake Hood’s oldest and largest seaplane operator, Rust’s was founded in 1963 by retired Air Force Colonel and WWII vet Henry “Hank” Rust. The types of flights offered by Rust’s range from hunting and fishing to flightseeing tours. The Cessna 208 Caravan was added to the their fleet in 2007. With a relatively high cruising speed and large windows for scenic tours... Читать дальше...